DMBT1

Gene Symbol DMBT1
Entrez Gene 1755
Alt Symbol GP340, muclin
Species Human
Gene Type protein-coding
Description deleted in malignant brain tumors 1
Other Description SAG|deleted in malignant brain tumors 1 protein|glycoprotein 340|gp-340|hensin|salivary agglutinin|surfactant pulmonary-associated D-binding protein
Swissprots A6NDJ5 Q9UJ57 Q59EX0 B1ARF0 Q9UGM2 A6NDG4 A8E4R5 Q5JR26 B7Z8Y2 Q6MZN4 B1ARE7 Q96DU4 Q9UGM3 B1ARE8 Q9Y4V9 B1ARE9 Q9UKJ4 Q9Y211 F8WEF7
Accessions BAA78577 CAB63941 CAB72255 CCQ43261 EAW49308 EAW49309 EAW49310 EAW49311 Q9UGM3 AB209691 BAD92928 AF159456 AAD49696 AJ000342 CAA04019 AJ243212 CAB56155 AJ243224 CAB63942 AJ297935 CAC44122 AK304128 BAG65024 AK304149 BAH14118 BC153299 AAI53300 BX640988 CAE45995 FJ234410 ACI95281 XM_006717660 XP_006717723 XM_006717665 XP_006717728 XM_011539388 XP_011537690 XM_011539389 XP_011537691 XM_011539390 XP_011537692 XM_011539391 XP_011537693 XM_011539392 XP_011537694 XM_011539393 XP_011537695 XM_011539394 XP_011537696 XM_011539395 XP_011537697 XM_011539396 XP_011537698 XM_011539397 XP_011537699 XM_011539398 XP_011537700 XM_011539399 XP_011537701 XM_011539400 XP_011537702 XM_011539401 XP_011537703 XM_011539402 XP_011537704 XM_011539403 XP_011537705 XM_011539404 XP_011537706 XM_011539405 XP_011537707 XM_011539406 XP_011537708 XM_011539407 XP_011537709 XM_011539408 XP_011537710 XM_011539409 XP_011537711 XM_011539410 XP_011537712 XM_011539411 XP_011537713 XM_011539412 XP_011537714 XM_011539413 XP_011537715 XM_011539414 XP_011537716 XM_011539415 XP_011537717 NM_004406 NP_004397 NM_007329 NP_015568 NM_017579 NP_060049
Function May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Bi
Subcellular Location Secreted {ECO:0000250}. Note=Some isoforms may be membrane-bound. Localized to the lumenal aspect of crypt cells in the small intestine. In the colon, seen in the lumenal aspect of surface epithelial cells. Formed in the ducts of von Ebner gland, and released into the fluid bathing the taste buds contained in the taste papillae (By similarity). {ECO:0000250}.
Tissue Specificity Highly expressed in alveolar and macrophage tissues. In some macrophages, expression is seen on the membrane, and in other macrophages, strongly expressed in the phagosome/phagolysosome compartments. Expressed in lung, trachea, salivary gland, small intestine and stomach. In pancreas, expressed in certain cells of the islets of Langerhans. In digestive tract, confined to tissues with large epithelial surfaces. In intestinal tissue, moderately expressed in epithelial cells of the midcrypts and the crypt base. Expression is significantly elevated in intestinal tissue from patients with inflammatory bowel disease (IBD), particularly in surface epithelial and Paneth cells, but not in IBD patients with mutant NOD2. Present in crypt bases of the duodenum, in crypt tops of the colon, and in collecting ducts of the cortical kidney. Expressed in stratified squamous epithelium of vagina and in outer luminar surface and basilar region of columnar epithelial cells in cervix (at protein level). Iso
Top Pathways Salivary secretion

DMBT1 (N-20) - sc-9572 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DMBT (N-20): sc-9572. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic staining.

DMBT1 (M-16) - sc-14249 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DMBT1 (M-16): sc-14249. Western blot analysis of DMBT1 expression in non-transfected: sc-117752 (A) and human DMBT1 transfected: sc-112667 (B) 293T whole cell lysates.

DMBT1 (D-20) - sc-9573 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DMBT1 (D-20): sc-9573. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing cytoplasmic staining of cells in seminiferous ducts and Leydig cells.

DMBT1 (P-20) - sc-14246 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DMBT1 (P-20): sc-14246. Western blot analysis of DMBT1 expression in EOC 20 whole cell lysate.

DMBT1 (H-130) - sc-28239 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DMBT1 (H-130): sc-28239. Immunoperoxidase staining of formalin fixed, paraffin-embedded human epididymis tissue showing cytoplasmic staining of glandular cells.

Anti-gp340 antibody - ab99175 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-gp340 antibody - ab96451 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-gp340 antibody (ab96451) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

Anti-gp340 antibody [5D7] - ab17779 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5D7
Localization of gp-340 by IHC-P staining of human lung with a streptavidin biotin immunocytochemical technique. The immunoreaction product, stained with ab17779 at a 1:50 dilution, is red and the section was counterstained with Mayers hematoxylin.  This application reveals high expression of gp-340 in alveolar macrophages

DMBT1/GP340 Antibody (5D7) - BSA Free - NBP1-05148 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5D7
Immunohistochemistry-Paraffin: DMBT1/GP340 Antibody (5D7) [NBP1-05148] - Localization of gp-340 by immunohistochemical staining of paraffin embedded section of human lung with a streptavidin biotin immunocytochemical technique. The immunoreaction product, stained with NBP1-05148, is red and the section was counterstained with Mayers hematoxylin.

DMBT1/GP340 Antibody - NBP2-38471 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: DMBT1/GP340 Antibody [NBP2-38471] - Staining of human lung shows strong cytoplasmic positivity in pneumocytes.

DMBT1/GP340 Antibody - NBP1-32891 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DMBT1/GP340 Antibody (1G4) - BSA Free - NBP2-23576 from Novus Biologicals

Prices $599.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone 1G4

DMBT1/GP340 Antibody - NBP1-57668 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DMBT1/GP340 Antibody [NBP1-57668] - Human Stomach, concentration 0.2-1 ug/ml.

GP340 Polyclonal Antibody - bs-0595R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded mouse stomach labeled with Anti-DMBT1/GP340 Polyclonal Antibody, Unconjugated (bs-0595R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-DMBT1 (C-terminal) antibody produced in rabbit - SAB2700429 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-DMBT1 (C-terminal): <B>Cat. No. SAB2700429</B>: Western Blot analysis of DMBT1 in extracts from <B>Lanes</B><BR/>A. H1299 using <B>Cat. No. SAB2700429</B> at a 1:1000 dilution.

Anti-DMBT1, (N-terminal) antibody produced in rabbit - SAB2105462 from Sigma-Aldrich

Prices $347.50
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-DMBT1 (N-Terminal): <B>Cat. No. SAB2105462</B>: DMBT1 in Fetal Stomach cell lysates with DMBT1 antibody at 1.0 μg/mL.

DMBT1 antibody - N-terminal region (ARP42352_P050) - ARP42352_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

gp340 antibody [C3-2], C-term - GTX110119 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-gp340 antibody [C3-2], C-term used in Western blot. GTX110119

Mouse DMBT1 Antibody - MAB59151 from R&D Systems

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Rat
Clone 548012
Detection of Mouse DMBT1 by Western Blot. Western blot shows lysates of mouse small intestine tissue. PVDF Membrane was probed with 2 µg/mL of Mouse DMBT1 Monoclonal Antibody (Catalog # MAB59151) followed by HRP-conjugated Anti-Rat IgG Secondary Antibody (Catalog # HAF005 ). A specific band was detected for DMBT1 at approximately 210 kDa (as indicated). This experiment was conducted under non-reducing conditions and using Immunoblot Buffer Group 1 .

Mouse DMBT1 MAb (Clone 548012), Rat IgG2B - MAB59151-SP from R&D Systems

Host Rat
Clonality Monoclonal
Clone 548012
Detection of Mouse DMBT1 by Western Blot. Western blot shows lysates of mouse small intestine tissue. PVDF Membrane was probed with 2 µg/mL of Mouse DMBT1 Monoclonal Antibody (Catalog # MAB59151) followed by HRP-conjugated Anti-Rat IgG Secondary Antibody (Catalog # HAF005). A specific band was detected for DMBT1 at approximately 210 kDa (as indicated). This experiment was conducted under non-reducing conditions and using Immunoblot Buffer Group 1.

Mouse DMBT1 Antibody - AF5915 from R&D Systems

Prices $99.00, $329.00
Sizes 25 µg, 100 µg
Host Goat
Detection of Mouse DMBT1 by Western Blot. Western blot shows lysates of mouse lung tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Mouse DMBT1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5915) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019 ). A specific band was detected for DMBT1 at approximately 240 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8 .

Mouse DMBT1 Affinity Purified Polyclonal Ab, Goat IgG - AF5915-SP from R&D Systems

Host Goat
Clonality Polyclonal
Detection of Mouse DMBT1 by Western Blot. Western blot shows lysates of mouse lung tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Mouse DMBT1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5915) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for DMBT1 at approximately 240 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

Mouse DMBT1 Antibody - MAB5915 from R&D Systems

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Rat
Clone 548031
Detection of DMBT1 in CMT-93 Mouse Cell Line by Flow Cytometry. CMT-93 mouse rectal carcinoma cell line was stained with Rat Anti-Mouse DMBT1 Monoclonal Antibody (Catalog # MAB5915, filled histogram) or isotype control antibody (Catalog # MAB0061 , open histogram), followed by Allophycocyanin-conjugated Anti-Rat IgG Secondary Antibody (Catalog # F0113 ).

Mouse DMBT1 MAb (Clone 548031), Rat IgG2B - MAB5915-SP from R&D Systems

Host Rat
Clonality Monoclonal
Clone 548031
Detection of DMBT1 in CMT‑93 Mouse Cell Line by Flow Cytometry. CMT‑93 mouse rectal carcinoma cell line was stained with Rat Anti-Mouse DMBT1 Monoclonal Antibody (Catalog # MAB5915, filled histogram) or isotype control antibody (Catalog # MAB0061, open histogram), followed by Allophycocyanin-conjugated Anti-Rat IgG Secondary Antibody (Catalog # F0113).

Gp340 antibody - orb73580 from Biorbyt

Prices $723.00
Sizes 100 μl
Host Rabbit
Clonality Polyclonal
Western Blot analysis of A:H1299 whole cell lysate using Gp340 antibody
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