Gene Symbol | CD248 |
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Entrez Gene | 57124 |
Alt Symbol | CD164L1, TEM1 |
Species | Human |
Gene Type | protein-coding |
Description | CD248 molecule, endosialin |
Other Description | 2610111G01Rik|CD164 sialomucin-like 1|CD248 antigen, endosialin|endosialin|tumor endothelial marker 1 |
Swissprots | Q9HCU0 Q3SX55 Q2M2V5 Q96KB6 |
Accessions | EAW74511 Q9HCU0 AF279142 AAG00867 AJ295846 CAC34381 AK027290 BAB55018 BC051340 AAH51340 BC098158 BC104484 AAI04485 BC105633 AAI05634 BQ005949 NM_020404 NP_065137 |
Function | May play a role in tumor angiogenesis. {ECO:0000269|PubMed:15862292}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
Tissue Specificity | Expressed in tumor endothelial cells but absent or barely detectable in normal endothelial cells. Expressed in metastatic lesions of the liver and during angiogenesis of corpus luteum formation and wound healing. Expressed in vascular endothelial cells of malignant tumors but not in normal blood vessels. Expressed in stromal fibroblasts. {ECO:0000269|PubMed:10947988, ECO:0000269|PubMed:11084048, ECO:0000269|PubMed:1438285, ECO:0000269|PubMed:15862292, ECO:0000269|PubMed:16076089}. |
TEM1 CRISPR/Cas9 KO Plasmid (h) - sc-405621 from Santa Cruz Biotechnology
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TEM1 HDR Plasmid (h) - sc-405621-HDR from Santa Cruz Biotechnology
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TEM1 Double Nickase Plasmid (h) - sc-405621-NIC from Santa Cruz Biotechnology
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TEM1 Double Nickase Plasmid (h2) - sc-405621-NIC-2 from Santa Cruz Biotechnology
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TEM1 CRISPR Activation Plasmid (h) - sc-405621-ACT from Santa Cruz Biotechnology
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TEM1 CRISPR Activation Plasmid (h2) - sc-405621-ACT-2 from Santa Cruz Biotechnology
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TEM1 Lentiviral Activation Particles (h) - sc-405621-LAC from Santa Cruz Biotechnology
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TEM1 Lentiviral Activation Particles (h2) - sc-405621-LAC-2 from Santa Cruz Biotechnology
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TEM1 siRNA (h) - sc-61659 from Santa Cruz Biotechnology
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TEM1 shRNA Plasmid (h) - sc-61659-SH from Santa Cruz Biotechnology
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TEM1 shRNA (h) Lentiviral Particles - sc-61659-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU003151 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5705 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5705 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01889 from Sigma-Aldrich
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CD248 siRNA (Human) - CRJ1339 from Cohesion Biosciences
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Endosialin/CD248/TEM1 RNAi - H00057124-R01 from Novus Biologicals
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CD248 - MBS8223922 from MyBioSource
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shRNA set against Human CD248 (NM_020404.2) - SHH258801 from Creative biogene
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shRNA set against Human CD248(NM_020404.2) - SHG156115 from Creative biogene
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Human CD248 siRNA - orb271840 from Biorbyt
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CD248 shRNA Plasmid (Human) - CHJ1339 from Cohesion Biosciences
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CD248 miRNA 3'UTR clone - MiUTR1H-01859 from Creative biogene
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