| Gene Symbol |
HSPH1
|
| Entrez Gene |
10808
|
| Alt Symbol |
HSP105, HSP105A, HSP105B, NY-CO-25
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
heat shock 105kDa/110kDa protein 1
|
| Other Description |
antigen NY-CO-25|heat shock 105kD alpha|heat shock 105kD beta|heat shock protein 105 kDa
|
| Swissprots |
Q5TBM8 B4DYH1 Q9UPC4 Q5TBM7 O95739 Q92598 Q5TBM6
|
| Accessions |
EAX08477 EAX08478 EAX08479 EAX08480 EAX08481 EAX08482 Q92598 AB003333 BAA34779 AB003334 BAA34780 AF039695 AAC18044 AK293955 BAG57329 AK302294 BAG63634 AK302430 BAG63733 AK302832 BAG64026 AK303029 BAG64155 AK307597 AK311464 AK314576 BC018124 BC037553 AAH37553 BX648125 BX648623 CD251908 D86956 BAA13192 DB069199 DB077644 DQ891727 ABM82653 DQ894904 ABM85830 XM_005266236 XP_005266293 XM_011534887 XP_011533189 XM_011534888 XP_011533190 NM_001286503 NP_001273432 NM_001286504 NP_001273433 NM_001286505 NP_001273434 NM_006644 NP_006635
|
| Function |
Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:9931472}.
|
| Tissue Specificity |
Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells. {ECO:0000269|PubMed:10865058, ECO:0000269|PubMed:16232202}.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|