SON

Gene Symbol SON
Entrez Gene 6651
Alt Symbol BASS1, C21orf50, DBP-5, NREBP, SON3
Species Human
Gene Type protein-coding
Description SON DNA binding protein
Other Description Bax antagonist selected in Saccharomyces 1|NRE-binding protein|negative regulatory element-binding protein|protein SON
Swissprots P18583 Q9UKP9 Q6PKE0 O95981 Q9P072 E7EVW3 Q9UPY0 E9PFQ2 Q14120 D3DSF5 O14487 D3DSF6 E7ETE8 E7EU67 Q9H7B1 Q9P070
Accessions AAA36624 EAX09814 EAX09815 EAX09816 EAX09817 EAX09818 EAX09819 EAX09820 EAX09821 EAX09822 EAX09823 EAX09824 P18583 AB028942 BAA82971 AF139897 AAD50078 AF161428 AAF28988 AF161430 AAF28990 AF380179 AAL34497 AF380180 AAL34498 AF380181 AAL34499 AF380182 AAL34500 AF380183 AAL34501 AF380184 AAL34502 AF435977 AAL30810 AK024752 BAB14985 AK074269 AK091233 BAG52313 AK127947 BAC87202 AK128071 AK307612 AW338543 AY026895 AAK07692 BC002422 AAH02422 BC005337 AAH05337 BC017278 BC029455 AAH29455 BC046101 BC054029 BC066303 BC104656 AAI04657 BF197677 BM998625 BQ221207 CF887020 CF890770 DQ102771 AAZ78117 EF212261 EF212262 X63071 CAA44793 X63751 CAC69885 X63753 CAA45282 NM_001291411 NP_001278340 NM_001291412 NP_001278341 NM_032195 NP_115571 NM_138927 NP_620305 NR_103797 NM_003103 NM_138925 NR_103796 NR_103798
Function RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'- GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830}.
Subcellular Location Nucleus speckle {ECO:0000269|PubMed:1424986, ECO:0000269|PubMed:21504830}. Note=Colocalizes with the pre-mRNA splicing factor SRSF2.
Tissue Specificity Widely expressed, with the higher expression seen in leukocyte and heart.

NREBP (C-10) - sc-398508 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NREBP (C-10): sc-398508. Western blot analysis of NREBP expression in AML-193 whole cell lysate.

NREBP (H-300) - sc-366496 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

NREBP (L-20) - sc-83734 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-SON antibody - ab109472 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab109472(1/200) staining SON in assynchronous HeLa cells (green). Cells were fixed in paraformaldehyde, permeabilised in 0.05% TritonX100/ PBS and counterstained with DAPI in order to highlight the nucleus (red). For further experimental details please refer to Abreview.See Abreview

Anti-SON antibody - ab121759 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SON antibody (ab121759) at 1/250 dilutionLane 1 : RT4 cell lysateLane 2 : U-251 MG cell lysateLane 3 : Human Plasma lysateLane 4 : Human Liver lysateLane 5 : Human Tonsil lysatedeveloped using the ECL technique

Anti-DBP5 / SON Antibody (aa1413-1628) - LS-C311913 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SON antibody used in ICC/IF.

Anti-DBP5 / SON Antibody (aa89-101) IHC-plus™ - LS-B9539 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-DBP5 / SON antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B9539 concentration 5 ug/ml.

SON Antibody - NBP1-88706 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SON Antibody [NBP1-88706] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

SON Antibody - 46460002 from Novus Biologicals

Prices $299.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SON antibody produced in rabbit - HPA023535 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SON: <B>Cat. No. HPA023535</B>: Immunohistochemical staining of human small intestine shows strong nuclear positivity in glandular cells.

SON-Antibody-N-Term - AF3503a from Abgent, a WuXi AppTec company

Prices $325.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Goat anti-SON -N-terminal region Antibody (OAEB02762) - OAEB02762 from Aviva Systems Biology

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SON Antibody - AC21-2465 from Abcore

Prices $359.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SON Antibody - AC11-0297 from Abcore

Prices $325.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SON Antibody (AMCA) - AC21-2465-01 from Abcore

Prices $495.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-SON Antibody (AP) - AC21-2465-02 from Abcore

Prices $505.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-SON Antibody (APC) - AC21-2465-03 from Abcore

Prices $515.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-SON Antibody (APC-Cy5.5) - AC21-2465-04 from Abcore

Prices $539.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-SON Antibody (APC-Cy7) - AC21-2465-05 from Abcore

Prices $539.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-SON Antibody (Avidin) - AC21-2465-06 from Abcore

Prices $519.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-SON Antibody (Biotin) - AC21-2465-07 from Abcore

Prices $519.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-SON Antibody (BPE) - AC21-2465-08 from Abcore

Prices $499.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-SON Antibody (Cy3) - AC21-2465-09 from Abcore

Prices $505.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-SON Antibody (Cy5) - AC21-2465-10 from Abcore

Prices $505.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-SON Antibody (Cy5.5) - AC21-2465-11 from Abcore

Prices $505.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
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