SON
| Gene Symbol | SON |
|---|---|
| Entrez Gene | 6651 |
| Alt Symbol | BASS1, C21orf50, DBP-5, NREBP, SON3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | SON DNA binding protein |
| Other Description | Bax antagonist selected in Saccharomyces 1|NRE-binding protein|negative regulatory element-binding protein|protein SON |
| Swissprots | P18583 Q9UKP9 Q6PKE0 O95981 Q9P072 E7EVW3 Q9UPY0 E9PFQ2 Q14120 D3DSF5 O14487 D3DSF6 E7ETE8 E7EU67 Q9H7B1 Q9P070 |
| Accessions | AAA36624 EAX09814 EAX09815 EAX09816 EAX09817 EAX09818 EAX09819 EAX09820 EAX09821 EAX09822 EAX09823 EAX09824 P18583 AB028942 BAA82971 AF139897 AAD50078 AF161428 AAF28988 AF161430 AAF28990 AF380179 AAL34497 AF380180 AAL34498 AF380181 AAL34499 AF380182 AAL34500 AF380183 AAL34501 AF380184 AAL34502 AF435977 AAL30810 AK024752 BAB14985 AK074269 AK091233 BAG52313 AK127947 BAC87202 AK128071 AK307612 AW338543 AY026895 AAK07692 BC002422 AAH02422 BC005337 AAH05337 BC017278 BC029455 AAH29455 BC046101 BC054029 BC066303 BC104656 AAI04657 BF197677 BM998625 BQ221207 CF887020 CF890770 DQ102771 AAZ78117 EF212261 EF212262 X63071 CAA44793 X63751 CAC69885 X63753 CAA45282 NM_001291411 NP_001278340 NM_001291412 NP_001278341 NM_032195 NP_115571 NM_138927 NP_620305 NR_103797 NM_003103 NM_138925 NR_103796 NR_103798 |
| Function | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'- GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830}. |
| Subcellular Location | Nucleus speckle {ECO:0000269|PubMed:1424986, ECO:0000269|PubMed:21504830}. Note=Colocalizes with the pre-mRNA splicing factor SRSF2. |
| Tissue Specificity | Widely expressed, with the higher expression seen in leukocyte and heart. |
Human SON protein fragment - ab152697 from Abcam
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Recombinant Human SON Protein - H00006651-Q01 from Novus Biologicals
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SON Immunizing peptide - orb66236 from Biorbyt
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SON Peptide - AC21-2465-P from Abcore
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SON / BASS1 - H00006651-Q01 from Acris Antibodies
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SON / BASS1 - H00006651-Q01-10 from Acris Antibodies
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SON / BASS1 - H00006651-Q01-25 from Acris Antibodies
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SON Peptide - 42-348P from ProSci
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Recombinant Human Protein SON(SON) ,partial - CSB-YP022403HU CSB-EP022403HU CSB-BP022403HU CSB-MP022403HU from Cusabio
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SON, Peptide - MBS427489 from MyBioSource
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SON Recombinant Protein Antigen - NBP1-88706PEP from Novus Biologicals
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SON Peptide, Human - M34GP14890H from Creative Peptides
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SON Recombinant Protein Antigen - NBP2-55412PEP from Novus Biologicals
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SON Recombinant Protein Antigen - NBP2-55411PEP from Novus Biologicals
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Protein SON (SON), partial, Recombinant Protein - MBS956631 from MyBioSource
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SON fusion protein - Ag27620 from Proteintech Group
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