| Gene Symbol |
Gfra2
|
| Entrez Gene |
14586
|
| Alt Symbol |
-
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
glial cell line derived neurotrophic factor family receptor alpha 2
|
| Other Description |
GDNF family receptor alpha-2|GDNF receptor alpha-2|GDNF receptor beta|GDNFR-alpha-2|GDNFR-beta|GFR alpha 2|GFR alpha-2|NRTNR-alpha|NTNR-alpha|TGF-beta-related neurotrophic factor receptor 2|neurturin receptor alpha
|
| Swissprots |
Q9Z2A3 Q9Z2A2 O08842 Q920Y3 Q3UUD8
|
| Accessions |
AAK97483 EDL35875 EDL35876 O08842 AF002701 AAC53548 AF079107 AAC82464 AF079108 AAC82465 AI462772 AK133028 AK138512 BAE23689 AK140225 AK149349 BAE28825 AK154579 BC138561 AAI38562 BY257515 CN539269 XM_011244958 XP_011243260 NM_001302094 NP_001289023 NM_001302095 NP_001289024 NM_008115 NP_032141
|
| Function |
Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. {ECO:0000269|PubMed:9182803}.
|
| Subcellular Location |
Cell membrane {ECO:0000305|PubMed:9182803}; Lipid-anchor, GPI-anchor {ECO:0000305|PubMed:9182803}.
|
| Tissue Specificity |
Neurons of the superior cervical and dorsal root ganglia, and adult brain and testis. Low level in the substantia nigra, spleen and adrenal gland (PubMed:9182803). Isoform 1, isoform 2 and isoform 3 are all expressed in brain, liver, ileum, spleen, heart and kidney (PubMed:9875703). In brain, isoform 1 is most abundant, isoform 2 slightly less and isoform 3 is lowest. No significant levels of isoform 1, isoform 2 or isoform 3 expression in testis (PubMed:12829325). {ECO:0000269|PubMed:12829325, ECO:0000269|PubMed:9182803, ECO:0000269|PubMed:9875703}.
|