| Gene Symbol | Gfra2 |
|---|---|
| Entrez Gene | 14586 |
| Alt Symbol | - |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | glial cell line derived neurotrophic factor family receptor alpha 2 |
| Other Description | GDNF family receptor alpha-2|GDNF receptor alpha-2|GDNF receptor beta|GDNFR-alpha-2|GDNFR-beta|GFR alpha 2|GFR alpha-2|NRTNR-alpha|NTNR-alpha|TGF-beta-related neurotrophic factor receptor 2|neurturin receptor alpha |
| Swissprots | Q9Z2A3 Q9Z2A2 O08842 Q920Y3 Q3UUD8 |
| Accessions | AAK97483 EDL35875 EDL35876 O08842 AF002701 AAC53548 AF079107 AAC82464 AF079108 AAC82465 AI462772 AK133028 AK138512 BAE23689 AK140225 AK149349 BAE28825 AK154579 BC138561 AAI38562 BY257515 CN539269 XM_011244958 XP_011243260 NM_001302094 NP_001289023 NM_001302095 NP_001289024 NM_008115 NP_032141 |
| Function | Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. {ECO:0000269|PubMed:9182803}. |
| Subcellular Location | Cell membrane {ECO:0000305|PubMed:9182803}; Lipid-anchor, GPI-anchor {ECO:0000305|PubMed:9182803}. |
| Tissue Specificity | Neurons of the superior cervical and dorsal root ganglia, and adult brain and testis. Low level in the substantia nigra, spleen and adrenal gland (PubMed:9182803). Isoform 1, isoform 2 and isoform 3 are all expressed in brain, liver, ileum, spleen, heart and kidney (PubMed:9875703). In brain, isoform 1 is most abundant, isoform 2 slightly less and isoform 3 is lowest. No significant levels of isoform 1, isoform 2 or isoform 3 expression in testis (PubMed:12829325). {ECO:0000269|PubMed:12829325, ECO:0000269|PubMed:9182803, ECO:0000269|PubMed:9875703}. |
GFRα-2 CRISPR/Cas9 KO Plasmid (m) - sc-420540 from Santa Cruz Biotechnology
|
||||||||
GFRα-2 HDR Plasmid (m) - sc-420540-HDR from Santa Cruz Biotechnology
|
||||||||
GFRα-2 Double Nickase Plasmid (m) - sc-420540-NIC from Santa Cruz Biotechnology
|
||||||||
GFRα-2 Double Nickase Plasmid (m2) - sc-420540-NIC-2 from Santa Cruz Biotechnology
|
||||||||
GFRα-2 CRISPR Activation Plasmid (m) - sc-420540-ACT from Santa Cruz Biotechnology
|
||||||||
GFRα-2 CRISPR Activation Plasmid (m2) - sc-420540-ACT-2 from Santa Cruz Biotechnology
|
||||||||
GFRα-2 Lentiviral Activation Particles (m) - sc-420540-LAC from Santa Cruz Biotechnology
|
||||||||
GFRα-2 Lentiviral Activation Particles (m2) - sc-420540-LAC-2 from Santa Cruz Biotechnology
|
||||||||
GFRα-2 siRNA (m) - sc-35472 from Santa Cruz Biotechnology
|
||||||||
GFRα-2 shRNA Plasmid (m) - sc-35472-SH from Santa Cruz Biotechnology
|
||||||||
GFRα-2 shRNA (m) Lentiviral Particles - sc-35472-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EMU081861 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN31845 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31845 from Sigma-Aldrich
|
||||||||
GFRA2 siRNA (Mouse) - CRM1546 from Cohesion Biosciences
|
||||||||
GFRA2 - MBS8213945 from MyBioSource
|
||||||||
shRNA set against Mouse GFRA2 (NM_008115.2) - SHH300690 from Creative biogene
|
||||||||
shRNA set against Mouse Gfra2(NM_008115.2) - SHH082685 from Creative biogene
|
||||||||
Mouse GFRA2 siRNA - orb281022 from Biorbyt
|
||||||||
GFRA2 shRNA Plasmid (Mouse) - CHM1546 from Cohesion Biosciences
|
||||||||
GFRA2 miRNA 3'UTR clone - MiUTR1M-05008 from Creative biogene
|