| Gene Symbol | FCGR3B |
|---|---|
| Entrez Gene | 2215 |
| Alt Symbol | CD16, CD16b, FCG3, FCGR3, FCR-10, FCRIII, FCRIIIb |
| Species | Human |
| Gene Type | protein-coding |
| Description | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) |
| Other Description | Fc-gamma receptor IIIb (CD 16)|fc-gamma RIII-beta|fc-gamma RIIIb|igG Fc receptor III-1|low affinity immunoglobulin gamma Fc region receptor III-B |
| Swissprots | O75015 |
| Accessions | ACS66846 ACS66847 ACS66848 ACS66849 ACS66850 ACS66854 ACS66855 ACS66856 ACS66857 ACS66858 ACS66859 CAA86296 O75015 AB025256 BAA83803 AJ581669 CAE46408 AK313219 AK316565 BAG38154 BC128562 AAI28563 DA669913 DA670720 DA671001 DA672751 DA672763 DA673839 DC428645 DC428702 J04162 AAA35881 M24854 AAA53507 X07934 CAA30758 X16863 CAA34753 NM_000570 NP_000561 NM_001244753 NP_001231682 NM_001271035 NP_001257964 NM_001271036 NP_001257965 NM_001271037 NP_001257966 |
| Function | Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. |
| Subcellular Location | Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage. |
| Tissue Specificity | Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils. |
| Top Pathways | Natural killer cell mediated cytotoxicity, Systemic lupus erythematosus, Leishmaniasis, Phagosome, Staphylococcus aureus infection |