CD74

Gene Symbol	CD74
Entrez Gene	972
Alt Symbol	DHLAG, HLADG, II, Ia-GAMMA
Species	Human
Gene Type	protein-coding
Description	CD74 molecule, major histocompatibility complex, class II invariant chain
Other Description	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)|HLA class II histocompatibility antigen gamma chain|HLA-DR antigens-associated invariant chain|HLA-DR-gamma|Ia-associated invariant chain|MHC HLA-DR gamma chain|gamma chain of class II antigens|p33
Swissprots	D3DQG3 A8K7R1 Q8SNA0 B4DNE8 Q8WLP6 Q5U0J8 D3DQG4 Q14597 Q29832 P04233
Accessions	AAA36033 CAA27046 CAA27047 EAW61727 EAW61728 EAW61729 EAW61730 EAW61731 P04233 AK292076 BAF84765 AK297889 BAG60210 AK300669 BAG62354 AK308929 BC018726 AAH18726 BC024272 AAH24272 BF796148 BT019505 AAV38312 DC354760 DQ892005 ABM82931 DQ895194 ABM86120 K01144 AAA36304 M28588 AAA58655 M28589 AAO49820 M28590 AAA35996 X00497 CAA25192 NM_001025158 NP_001020329 NM_001025159 NP_001020330 NM_004355 NP_004346
Function	Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
Subcellular Location	Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.
Top Pathways	Tuberculosis, Herpes simplex infection, Antigen processing and presentation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CD 74 Gene - orb91589 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-CD74-cDNA-Clone - DC04743 from Abgent, a WuXi AppTec company Prices $313.20 Sizes 10 µg Species Human Accession BC018726

CD74 - MBS1268628 from MyBioSource Prices $475.00, $520.00 Sizes 10ug plasmid + 200ul glycerol stock (E Coli), 10ug plasmid + 200ul glycerol stock (Yeast) Species Human Accession BC018726

Human CD74 transcript variant 2 Gene ORF cDNA clone in cloning vector - HG11091-M from Sino Biological Species Human

Human CD74 transcript variant 2 Gene ORF cDNA clone expression plasmid - HG11091-UT from Sino Biological Species Human

Human CD74 transcript variant 2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11091-NY from Sino Biological Species Human

Human CD74 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11091-ACG from Sino Biological Species Human

Human CD74 transcript variant 2 Gene ORF cDNA clone expression plasmid, N-His tag - HG11091-NH from Sino Biological Species Human

Human CD74 transcript variant 2 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG11091-M-F from Sino Biological Species Human Accession NM_004355.2

Human CD74 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-His tag - HG11091-CH from Sino Biological Species Human

Human CD74 transcript variant 2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11091-NF from Sino Biological Species Human

Human CD74 transcript variant 2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11091-NM from Sino Biological Species Human

Human CD74 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11091-CF from Sino Biological Species Human

Human CD74 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11091-CM from Sino Biological Species Human

Human CD74 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11091-ACR from Sino Biological Species Human

Human CD74 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11091-CY from Sino Biological Species Human

Human CD74 ORF Clone (BC018726) - CDCS406690 from Creative biogene Species Human Accession P04233

Search more