CD74

Gene Symbol	CD74
Entrez Gene	972
Alt Symbol	DHLAG, HLADG, II, Ia-GAMMA
Species	Human
Gene Type	protein-coding
Description	CD74 molecule, major histocompatibility complex, class II invariant chain
Other Description	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)|HLA class II histocompatibility antigen gamma chain|HLA-DR antigens-associated invariant chain|HLA-DR-gamma|Ia-associated invariant chain|MHC HLA-DR gamma chain|gamma chain of class II antigens|p33
Swissprots	D3DQG3 A8K7R1 Q8SNA0 B4DNE8 Q8WLP6 Q5U0J8 D3DQG4 Q14597 Q29832 P04233
Accessions	AAA36033 CAA27046 CAA27047 EAW61727 EAW61728 EAW61729 EAW61730 EAW61731 P04233 AK292076 BAF84765 AK297889 BAG60210 AK300669 BAG62354 AK308929 BC018726 AAH18726 BC024272 AAH24272 BF796148 BT019505 AAV38312 DC354760 DQ892005 ABM82931 DQ895194 ABM86120 K01144 AAA36304 M28588 AAA58655 M28589 AAO49820 M28590 AAA35996 X00497 CAA25192 NM_001025158 NP_001020329 NM_001025159 NP_001020330 NM_004355 NP_004346
Function	Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
Subcellular Location	Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.
Top Pathways	Tuberculosis, Herpes simplex infection, Antigen processing and presentation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human MHC Class II Ia protein fragment - ab174039 from Abcam Category Protein Prices $428.00 Sizes 100 µg Source HEK 293 cells Species Human

CD74 peptide - ab203482 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human CD74 full length protein - ab158067 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human CD74 peptide - ab74386 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human CD74 protein fragment - ab156328 from Abcam Category Protein Prices $297.00 Sizes 100 µg Source E. coli Species Human

Human CD74 protein fragment - ab201901 from Abcam Category Protein Prices $429.00 Sizes 50 µg Source Insect cells Species Human

CD74 Recombinant Protein - H00000972-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human CD74 Protein - NBP2-22758 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

CD74 Recombinant Protein - H00000972-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

Recombinant Human CD74, CF - 3590-CD-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Gln73-Met232, with an N-terminal HA (YPYDVPDYA) tag

Human CD74 His tag protein - orb83418 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

Human CD74 protein - orb191375 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

CD74 protein - 80R-4272 from Fitzgerald Category Protein Prices $295.00 Sizes 50 µg Source Insect cells

CD74 protein (His tag) - 80R-2809 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

CD74 (73-232, His-tag) - AR50928PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

CD74 (73-232, His-tag) - AR50928PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

CD74 (73-232, His-tag) - AR51954PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Species Human

CD74 (73-232, His-tag) - AR51954PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Species Human

CD74 - H00000972-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD74 - H00000972-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

CD74, 73-232aa, Human, His tag, E.coli - 01-P2104 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

CD74 Recombinant Protein - 96-110 from ProSci Category Protein Prices $425.00 Sizes 100 µg Source HEK293 cells Species Human

CD74 fusion protein - ag13449 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human CD74, His tagged - CD74-2227H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human CD74, Myc-DDK-Tagged - CD74-2228H from Creative Biomart Category Protein Source Human HEK293 cells

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