| Gene Symbol | NEK2 |
|---|---|
| Entrez Gene | 4751 |
| Alt Symbol | HsPK21, NEK2A, NLK1, PPP1R111, RP67 |
| Species | Human |
| Gene Type | protein-coding |
| Description | NIMA-related kinase 2 |
| Other Description | NIMA (never in mitosis gene a)-related kinase 2|nimA-like protein kinase 1|nimA-related protein kinase 2|protein phosphatase 1, regulatory subunit 111|serine/threonine-protein kinase Nek2 |
| Swissprots | Q7Z634 Q6NZX8 Q5I1Z9 Q5VXZ1 P51955 Q53FD6 Q86XH2 Q96QN9 |
| Accessions | EAW93410 EAW93411 P51955 AK223353 BAD97073 AK225522 AK303092 BAG64202 AY045701 AAK92212 AY863109 AAW56418 BC043502 AAH43502 BC052807 AAH52807 BC065932 AAH65932 BT019729 AAV38534 BU517064 DC407297 DQ786247 DQ786281 U11050 AAA19558 Z25425 CAA80912 Z29066 CAA82309 XM_005273147 XP_005273204 NM_001204182 NP_001191111 NM_001204183 NP_001191112 NM_002497 NP_002488 |
| Function | Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGOL1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S- arrested cells. Isoform 2, which is not present in the nucleolus, does not. {ECO:0 |
| Subcellular Location | Isoform 4: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Predominantly nuclear. |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in peripheral blood T-cells and a wide variety of transformed cell types. Isoform 1 and isoform 4 are expressed in the testis. Up- regulated in various cancer cell lines, as well as primary breast tumors. {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:15659832}. |