NEK2

Gene Symbol	NEK2
Entrez Gene	4751
Alt Symbol	HsPK21, NEK2A, NLK1, PPP1R111, RP67
Species	Human
Gene Type	protein-coding
Description	NIMA-related kinase 2
Other Description	NIMA (never in mitosis gene a)-related kinase 2|nimA-like protein kinase 1|nimA-related protein kinase 2|protein phosphatase 1, regulatory subunit 111|serine/threonine-protein kinase Nek2
Swissprots	Q7Z634 Q6NZX8 Q5I1Z9 Q5VXZ1 P51955 Q53FD6 Q86XH2 Q96QN9
Accessions	EAW93410 EAW93411 P51955 AK223353 BAD97073 AK225522 AK303092 BAG64202 AY045701 AAK92212 AY863109 AAW56418 BC043502 AAH43502 BC052807 AAH52807 BC065932 AAH65932 BT019729 AAV38534 BU517064 DC407297 DQ786247 DQ786281 U11050 AAA19558 Z25425 CAA80912 Z29066 CAA82309 XM_005273147 XP_005273204 NM_001204182 NP_001191111 NM_001204183 NP_001191112 NM_002497 NP_002488
Function	Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGOL1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S- arrested cells. Isoform 2, which is not present in the nucleolus, does not. {ECO:0
Subcellular Location	Isoform 4: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Predominantly nuclear.
Tissue Specificity	Isoform 1 and isoform 2 are expressed in peripheral blood T-cells and a wide variety of transformed cell types. Isoform 1 and isoform 4 are expressed in the testis. Up- regulated in various cancer cell lines, as well as primary breast tumors. {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:15659832}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human NEK2 full length protein - ab60342 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human NEK2 full length protein - ab42599 from Abcam Category Protein Prices $321.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human NEK2 protein fragment - ab152565 from Abcam Category Protein Source Wheat germ Species Human

NEK2 Antibody Blocking Peptide - LS-E17571 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NEK2 Antibody Blocking Peptide - LS-E9472 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NEK2 Antibody Blocking Peptide - LS-E9473 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NEK2 Partial Recombinant Protein - H00004751-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

NEK2 Recombinant Protein - P4203 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

NEK2 Recombinant Protein - P3884 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

Recombinant Human NEK2 Protein - P4731 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source Insect Species Human

Recombinant NEK2 Protein - NBP1-99488 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

NEK2 Peptide - P3070 from Novus Biologicals Category Peptide Species Human

NEK2 Peptide - P3069 from Novus Biologicals Category Peptide Species Human

NEK2-Antibody-Center-Blocking-Peptide - BP8074c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NEK2-Antibody-Center-Blocking-Peptide - BP8073c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Active NEK2, CF - 3706-KS-010 from R&D Systems Category Protein

NEK2 - H00004751-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NEK2 - H00004751-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NEK2 - P3884 from Acris Antibodies Category Protein Prices $1,230.00 Sizes 5 µg Species Human

NEK2 - P4203 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

NEK2 - P4731 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

NEK2 - P5733 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 5 µg Species Human

NEK2 fusion protein - Ag5474 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

NEK2 fusion protein - ag5632 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

NEK2 fusion protein - ag21476 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

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