| Gene Symbol |
Magel2
|
| Entrez Gene |
27385
|
| Alt Symbol |
Mage-l2, NDNL1, nM15, ns7
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
melanoma antigen, family L, 2
|
| Other Description |
MAGE-like protein 2|melanoma antigen-like gene 2|necdin-like 1|protein nS7
|
| Swissprots |
Q9QZ04
|
| Accessions |
AAF97424 Q9QZ04 AJ243608 CAB62395 AK082944 AK086725 BC054763 AAH54763 BC062913 BC071222 AAH71222 NM_013779 NP_038807
|
| Function |
Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys- 63'-linked polyubiquitin chains at 'Lys-220' of WASH1 together with TRIM27, leading to promote endosomal F-actin assembly (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK (PubMed:22208286). {ECO:0000250|UniProtKB:Q9UJ55, ECO:0000269|PubMed:22208286}.
|
| Subcellular Location |
Early endosome. Cytoplasm {ECO:0000269|PubMed:22208286}. Nucleus {ECO:0000269|PubMed:22208286}. Note=Recruited to retromer- containing endosomes via interaction with VPS35. Colocalizes with CLOCK and ARNTL/BMLA1 in the cytoplasm, and with PER2 in the cytoplasm and nucleus. {ECO:0000250|UniProtKB:Q9UJ55, ECO:0000269|PubMed:22208286}.
|
| Tissue Specificity |
Expressed predominantly in late development stages and adult brain. {ECO:0000269|PubMed:10915770}.
|
