| Gene Symbol | Magel2 |
|---|---|
| Entrez Gene | 27385 |
| Alt Symbol | Mage-l2, NDNL1, nM15, ns7 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | melanoma antigen, family L, 2 |
| Other Description | MAGE-like protein 2|melanoma antigen-like gene 2|necdin-like 1|protein nS7 |
| Swissprots | Q9QZ04 |
| Accessions | AAF97424 Q9QZ04 AJ243608 CAB62395 AK082944 AK086725 BC054763 AAH54763 BC062913 BC071222 AAH71222 NM_013779 NP_038807 |
| Function | Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys- 63'-linked polyubiquitin chains at 'Lys-220' of WASH1 together with TRIM27, leading to promote endosomal F-actin assembly (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK (PubMed:22208286). {ECO:0000250|UniProtKB:Q9UJ55, ECO:0000269|PubMed:22208286}. |
| Subcellular Location | Early endosome. Cytoplasm {ECO:0000269|PubMed:22208286}. Nucleus {ECO:0000269|PubMed:22208286}. Note=Recruited to retromer- containing endosomes via interaction with VPS35. Colocalizes with CLOCK and ARNTL/BMLA1 in the cytoplasm, and with PER2 in the cytoplasm and nucleus. {ECO:0000250|UniProtKB:Q9UJ55, ECO:0000269|PubMed:22208286}. |
| Tissue Specificity | Expressed predominantly in late development stages and adult brain. {ECO:0000269|PubMed:10915770}. |
Recombinant Mouse MAGE-like protein 2(Magel2) - CSB-YP874135MO CSB-EP874135MO CSB-BP874135MO CSB-MP874135MO from Cusabio
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MAGE-like protein 2 (Magel2), Recombinant Protein - MBS1479303 from MyBioSource
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