ATP2A2

Gene Symbol	ATP2A2
Entrez Gene	488
Alt Symbol	ATP2B, DAR, DD, SERCA2
Species	Human
Gene Type	protein-coding
Description	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Other Description	ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2|SR Ca(2+)-ATPase 2|calcium pump 2|calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform|cardiac Ca2+ ATPase|endoplasmic reticulum class 1/2 Ca(2+) ATPase|sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Swissprots	P16615 Q86VJ2 P16614 A6NDN7 B4DF05
Accessions	AAA52757 AAA52758 ABY71268 ACA51040 EAW97902 EAW97903 EAW97904 EAW97905 EAW97906 EAW97907 P16615 AK000300 AK095382 AK293877 BAG57266 AL117505 AY186578 AAO47398 BC035588 AAH35588 BC065753 BG773489 BI553880 BX648282 M23114 AAA53193 M23115 AAA53194 XM_005253888 XP_005253945 XM_011538402 XP_011536704 XM_011538403 XP_011536705 XR_243009 NM_001681 NP_001672 NM_170665 NP_733765 NM_001135765
Function	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle. {ECO:0000269|PubMed:16402920}.
Subcellular Location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue Specificity	Isoform 1 is widely expressed in smooth muscle and nonmuscle tissues such as in adult skin epidermis, with highest expression in liver, pancreas and lung, and intermediate expression in brain, kidney and placenta. Also expressed at lower levels in heart and skeletal muscle. Isoforms 2 and 3 are highly expressed in the heart and slow twitch skeletal muscle. Expression of isoform 3 is predominantly restricted to cardiomyocytes and in close proximity to the sarcolemma. Both isoforms are mildly expressed in lung, kidney, liver, pancreas and placenta. Expression of isoform 3 is amplified during monocytic differentiation and also observed in the fetal heart. {ECO:0000269|PubMed:10441324, ECO:0000269|PubMed:12659872, ECO:0000269|PubMed:16402920}.
Top Pathways	cAMP signaling pathway, Alzheimer's disease, cGMP-PKG signaling pathway, Adrenergic signaling in cardiomyocytes, Pancreatic secretion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SERCA2 ATPase peptide - ab90832 from Abcam Category Peptide

Human SERCA2 ATPase peptide - ab91426 from Abcam Category Peptide

ATP2A2 / SERCA2 Antibody Blocking Peptide - LS-E4651 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ATP2A2 / SERCA2 Antibody Blocking Peptide - LS-E16547 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SERCA2 ATPase Protein - H00000488-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

ATP2A2-Antibody-Center-Blocking-peptide - BP12148c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ATP2A2-Antibody-Center-Blocking-Peptide - BP17013c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ATP2A2 Blocking Peptide - 33R-9709 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SERCA2 Blocking Peptide - abx064126 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey, Rabbit

ATP2A2 / SERCA2 - H00000488-P01-2 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

SERCA2,ATP2A2 fusion protein - Ag5052 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, T-HIS Species Human

Recombinant ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) - RPG374Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) - RPG374Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) - RPG374Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

SERCA2 Blocking Peptide - CBP2932 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey, Rabbit

Recombinant ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) - RPG374Hu01 from Cloud-clone Category Protein Source E.coli Species Human

ATPase, Ca++ TransPorting, Cardiac Muscle, Slow Twitch 2 Protein (Recombinant) - abx167004 from Abbexa Category Protein Source Human Species Human

SERCA2/ATP2A2, Peptide - MBS428382 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig

SERCA2 ATPase Protein - NBP2-34147PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

ATP2A2 Peptide, Human - M34GP01142H from Creative Peptides Category Peptide Source Synthetic. Species Human

ATP2A2 Recombinant Protein (OPCA01475) - OPCA01475 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Human ATP2A2 protein - orb358070 from Biorbyt Category Protein Prices $221.00, $366.00, $646.00, $1,071.00, $1,692.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

Recombinant Human Sarcoplasmic/endoplasmic reticulum calcium ATPase 2(ATP2A2),partial - CSB-EP002333HU from Cusabio Category Protein Source E.coli Species Human

Recombinant ATPase, Ca++ TransPorting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) - RPU53212 from Biomatik Category Protein Prices $194.00, $396.00, $605.00, $721.60 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

ATP2A2 Recombinant Protein (OPCD01540) - OPCD01540 from Aviva Systems Biology Category Protein Source E.coli Species Human

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