ATP2A2
| Gene Symbol | ATP2A2 |
|---|---|
| Entrez Gene | 488 |
| Alt Symbol | ATP2B, DAR, DD, SERCA2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 |
| Other Description | ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2|SR Ca(2+)-ATPase 2|calcium pump 2|calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform|cardiac Ca2+ ATPase|endoplasmic reticulum class 1/2 Ca(2+) ATPase|sarcoplasmic/endoplasmic reticulum calcium ATPase 2 |
| Swissprots | P16615 Q86VJ2 P16614 A6NDN7 B4DF05 |
| Accessions | AAA52757 AAA52758 ABY71268 ACA51040 EAW97902 EAW97903 EAW97904 EAW97905 EAW97906 EAW97907 P16615 AK000300 AK095382 AK293877 BAG57266 AL117505 AY186578 AAO47398 BC035588 AAH35588 BC065753 BG773489 BI553880 BX648282 M23114 AAA53193 M23115 AAA53194 XM_005253888 XP_005253945 XM_011538402 XP_011536704 XM_011538403 XP_011536705 XR_243009 NM_001681 NP_001672 NM_170665 NP_733765 NM_001135765 |
| Function | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle. {ECO:0000269|PubMed:16402920}. |
| Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein. |
| Tissue Specificity | Isoform 1 is widely expressed in smooth muscle and nonmuscle tissues such as in adult skin epidermis, with highest expression in liver, pancreas and lung, and intermediate expression in brain, kidney and placenta. Also expressed at lower levels in heart and skeletal muscle. Isoforms 2 and 3 are highly expressed in the heart and slow twitch skeletal muscle. Expression of isoform 3 is predominantly restricted to cardiomyocytes and in close proximity to the sarcolemma. Both isoforms are mildly expressed in lung, kidney, liver, pancreas and placenta. Expression of isoform 3 is amplified during monocytic differentiation and also observed in the fetal heart. {ECO:0000269|PubMed:10441324, ECO:0000269|PubMed:12659872, ECO:0000269|PubMed:16402920}. |
| Top Pathways | cAMP signaling pathway, Alzheimer's disease, cGMP-PKG signaling pathway, Adrenergic signaling in cardiomyocytes, Pancreatic secretion |
SERCA2 CRISPR/Cas9 KO Plasmid (h) - sc-400417 from Santa Cruz Biotechnology
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SERCA2 HDR Plasmid (h) - sc-400417-HDR from Santa Cruz Biotechnology
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SERCA2 Double Nickase Plasmid (h) - sc-400417-NIC from Santa Cruz Biotechnology
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SERCA2 Double Nickase Plasmid (h2) - sc-400417-NIC-2 from Santa Cruz Biotechnology
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SERCA2 CRISPR Activation Plasmid (h) - sc-400417-ACT from Santa Cruz Biotechnology
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SERCA2 CRISPR Activation Plasmid (h2) - sc-400417-ACT-2 from Santa Cruz Biotechnology
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SERCA2 Lentiviral Activation Particles (h) - sc-400417-LAC from Santa Cruz Biotechnology
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SERCA2 Lentiviral Activation Particles (h2) - sc-400417-LAC-2 from Santa Cruz Biotechnology
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SERCA2 siRNA (h) - sc-36484 from Santa Cruz Biotechnology
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SERCA2 shRNA Plasmid (h) - sc-36484-SH from Santa Cruz Biotechnology
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SERCA2 shRNA (h) Lentiviral Particles - sc-36484-V from Santa Cruz Biotechnology
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SERCA2 ATPase RNAi - H00000488-R03 from Novus Biologicals
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SERCA2 ATPase RNAi - H00000488-R04 from Novus Biologicals
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MISSION® esiRNA - EHU069091 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3687 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3687 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06777 from Sigma-Aldrich
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ATP2A2 siRNA (Human) - CRH0342 from Cohesion Biosciences
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ATP2A2 - MBS8226142 from MyBioSource
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shRNA set against Human ATP2A2 (NM_001681.3) - SHH242614 from Creative biogene
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shRNA set against Human ATP2A2(NM_001681.3) - SHG033433 from Creative biogene
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shRNA set against Human ATP2A2(NM_170665.3) - SHG033505 from Creative biogene
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shRNA set against Human ATP2A2(NM_001681.3) - SHG033523 from Creative biogene
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ATP2A2 shRNA Plasmid (Human) - CHH0342 from Cohesion Biosciences
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ATP2A2 miRNA 3'UTR clone - MiUTR1H-00682 from Creative biogene
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