| Gene Symbol | CYSLTR2 |
|---|---|
| Entrez Gene | 57105 |
| Alt Symbol | CYSLT2, CYSLT2R, HG57, HPN321, KPG_011, PSEC0146, hGPCR21 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cysteinyl leukotriene receptor 2 |
| Other Description | G protein-coupled receptor|G-protein coupled receptor GPCR21|G-protein coupled receptor HG57|cysteinyl leukotriene CysLT2 receptor |
| Swissprots | Q9NS75 Q9HCQ2 |
| Accessions | AAG17281 AAK69485 AAQ91330 BAB16379 BAB89316 CAC69300 CAC69324 CAD19004 CAD20523 CAD35281 CAD68128 CAJ58194 EAX08802 Q9NS75 AB038269 BAB03601 AB041947 BAD83598 AK291739 BAF84428 AY853711 AAW47925 BC069160 AAH69160 BC096832 AAH96832 EF141523 ABO61874 EF141524 ABO61875 EF141525 ABO61876 EF141526 ABO61877 EF141527 ABO61878 EF141528 ABO61879 EF141529 ABO61880 EF141530 ABO61881 NM_001308465 NP_001295394 NM_001308467 NP_001295396 NM_001308468 NP_001295397 NM_001308469 NP_001295398 NM_001308470 NP_001295399 NM_001308471 NP_001295400 NM_001308476 NP_001295405 NM_020377 NP_065110 |
| Function | Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells. |
| Top Pathways | Calcium signaling pathway, Neuroactive ligand-receptor interaction |
CysLT 2 Receptor CRISPR/Cas9 KO Plasmid (h) - sc-403435 from Santa Cruz Biotechnology
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CysLT 2 Receptor HDR Plasmid (h) - sc-403435-HDR from Santa Cruz Biotechnology
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CysLT 2 Receptor Double Nickase Plasmid (h) - sc-403435-NIC from Santa Cruz Biotechnology
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CysLT 2 Receptor Double Nickase Plasmid (h2) - sc-403435-NIC-2 from Santa Cruz Biotechnology
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CysLT 2 Receptor CRISPR Activation Plasmid (h) - sc-403435-ACT from Santa Cruz Biotechnology
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CysLT 2 Receptor CRISPR Activation Plasmid (h2) - sc-403435-ACT-2 from Santa Cruz Biotechnology
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CysLT 2 Receptor Lentiviral Activation Particles (h) - sc-403435-LAC from Santa Cruz Biotechnology
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CysLT 2 Receptor Lentiviral Activation Particles (h2) - sc-403435-LAC-2 from Santa Cruz Biotechnology
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CysLT 2 Receptor siRNA (h) - sc-43713 from Santa Cruz Biotechnology
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CysLT 2 Receptor shRNA Plasmid (h) - sc-43713-SH from Santa Cruz Biotechnology
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CysLT 2 Receptor shRNA (h) Lentiviral Particles - sc-43713-V from Santa Cruz Biotechnology
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Cysteinyl Leukotriene R2/CysLTR2 RNAi - H00057105-R02 from Novus Biologicals
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MISSION® esiRNA - EHU001281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6898 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6898 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09653 from Sigma-Aldrich
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CYSLTR2 siRNA (Human) - CRJ1325 from Cohesion Biosciences
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CYSLTR2 - MBS8239782 from MyBioSource
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CysLT2 Receptor CRISPR/Cas9 KO Plasmid (h2) - sc-403435-KO-2 from Santa Cruz Biotechnology
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CysLT2 Receptor HDR Plasmid (h2) - sc-403435-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CYSLTR2 (NM_020377.2) - SHH273889 from Creative biogene
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shRNA set against Human CYSLTR2(NM_020377.2) - SHG218383 from Creative biogene
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Human CYSLTR2 siRNA - orb271826 from Biorbyt
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CYSLTR2 shRNA Plasmid (Human) - CHJ1325 from Cohesion Biosciences
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CYSLTR2 miRNA 3'UTR clone - MiUTR1H-02647 from Creative biogene
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