| Gene Symbol |
UBA1
|
| Entrez Gene |
7317
|
| Alt Symbol |
A1S9, A1S9T, A1ST, AMCX1, CFAP124, GXP1, POC20, SMAX2, UBA1A, UBE1, UBE1X
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-like modifier activating enzyme 1
|
| Other Description |
A1S9T and BN75 temperature sensitivity complementing|POC20 centriolar protein homolog|UBA1, ubiquitin-activating enzyme E1 homolog A|ubiquitin-like modifier-activating enzyme 1
|
| Swissprots |
P22314 Q96E13 Q5JRR8
|
| Accessions |
CAA05866 EAW59290 EAW59291 EAW59292 EAW59293 P22314 AF258566 AAG23769 AK097343 BAG53454 AK131341 AK293161 BAG56705 AK296866 BAG59429 BC009900 BC013041 AAH13041 BC020261 BG703038 BI547207 EU176375 ABW03826 EU176712 ABW03513 M58028 AAA61246 X52897 CAA37078 X56976 CAA40296 XM_005272649 XP_005272706 XM_005272650 XP_005272707 XM_011543953 XP_011542255 XM_011543954 XP_011542256 XM_011543955 XP_011542257 XM_011543956 XP_011542258 NM_003334 NP_003325 NM_153280 NP_695012
|
| Function |
Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin- proteasome system. Activates ubiquitin by first adenylating its C- terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. {ECO:0000269|PubMed:22456334}.
|
| Subcellular Location |
Isoform 2: Cytoplasm.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|