UBA1

Gene Symbol UBA1
Entrez Gene 7317
Alt Symbol A1S9, A1S9T, A1ST, AMCX1, CFAP124, GXP1, POC20, SMAX2, UBA1A, UBE1, UBE1X
Species Human
Gene Type protein-coding
Description ubiquitin-like modifier activating enzyme 1
Other Description A1S9T and BN75 temperature sensitivity complementing|POC20 centriolar protein homolog|UBA1, ubiquitin-activating enzyme E1 homolog A|ubiquitin-like modifier-activating enzyme 1
Swissprots P22314 Q96E13 Q5JRR8
Accessions CAA05866 EAW59290 EAW59291 EAW59292 EAW59293 P22314 AF258566 AAG23769 AK097343 BAG53454 AK131341 AK293161 BAG56705 AK296866 BAG59429 BC009900 BC013041 AAH13041 BC020261 BG703038 BI547207 EU176375 ABW03826 EU176712 ABW03513 M58028 AAA61246 X52897 CAA37078 X56976 CAA40296 XM_005272649 XP_005272706 XM_005272650 XP_005272707 XM_011543953 XP_011542255 XM_011543954 XP_011542256 XM_011543955 XP_011542257 XM_011543956 XP_011542258 NM_003334 NP_003325 NM_153280 NP_695012
Function Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin- proteasome system. Activates ubiquitin by first adenylating its C- terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. {ECO:0000269|PubMed:22456334}.
Subcellular Location Isoform 2: Cytoplasm.
Top Pathways Ubiquitin mediated proteolysis

UBE1 CRISPR/Cas9 KO Plasmid (h) - sc-402844 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE1 HDR Plasmid (h) - sc-402844-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE1 Double Nickase Plasmid (h) - sc-402844-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE1 Double Nickase Plasmid (h2) - sc-402844-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE1 CRISPR Activation Plasmid (h) - sc-402844-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE1 CRISPR Activation Plasmid (h2) - sc-402844-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE1 Lentiviral Activation Particles (h) - sc-402844-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE1 Lentiviral Activation Particles (h2) - sc-402844-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE1 siRNA (h) - sc-61750 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UBE1 shRNA Plasmid (h) - sc-61750-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UBE1 shRNA (h) Lentiviral Particles - sc-61750-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ubiquitin-activating Enzyme/UBE1 RNAi - H00007317-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Ubiquitin-activating Enzyme/UBE1 RNAi - H00007317-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU080271 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22336 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22336 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00737 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00737

UBA1 siRNA (Human) - CRH5000 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UBA1 - MBS8223588 from MyBioSource

UBA1 - MBS8214723 from MyBioSource

UBA1 - MBS8219107 from MyBioSource

shRNA set against Human UBA1 (NM_003334.3) - SHH438636 from Creative biogene

Category siRNA
Species Reactivities Human

UBA1 shRNA Plasmid (Human) - CHH5000 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

UBA1 miRNA 3'UTR clone - MiUTR1H-10926 from Creative biogene

Species Reactivities Human

UBA1 miRNA 3'UTR clone - MiUTR3H-03030 from Creative biogene

Species Reactivities Human
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