| Gene Symbol |
SLC52A1
|
| Entrez Gene |
55065
|
| Alt Symbol |
GPCR42, GPR172B, PAR2, RBFVD, RFT1, RFVT1, hRFT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 52 (riboflavin transporter), member 1
|
| Other Description |
G protein-coupled receptor 172B|G-protein coupled receptor GPCR42|PERV-A receptor 2|porcine endogenous retrovirus A receptor 2|solute carrier family 52, riboflavin transporter, member 1
|
| Swissprots |
B5MEV2 Q9NWF4 Q86UT0 Q6P9E0 B5MEV1
|
| Accessions |
BAB89337 EAW90363 EAW90364 EAW90365 Q9NWF4 AB362533 BAG71128 AB362534 BAG71129 AK000922 BAA91427 AK023570 AK123566 BAG53914 AY070775 AAL59883 BC060810 AAH60810 BC092473 AAH92473 BU752646 DA383729 EU832193 ACE86763 JF432427 ADZ15644 XM_011523951 XP_011522253 NM_001104577 NP_001098047 NM_017986 NP_060456
|
| Function |
Riboflavin transporter. Riboflavin transport is Na(+)- independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A). {ECO:0000269|PubMed:12740431, ECO:0000269|PubMed:20463145}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:18632736, ECO:0000269|PubMed:20463145}; Multi-pass membrane protein {ECO:0000269|PubMed:18632736, ECO:0000269|PubMed:20463145}.
|
| Tissue Specificity |
Widely expressed. Highly expressed in the testis, placenta and small intestine. Expressed at lower level in other tissues. {ECO:0000269|PubMed:12740431, ECO:0000269|PubMed:18632736, ECO:0000269|PubMed:20463145}.
|