Gene Symbol | SLC52A1 |
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Entrez Gene | 55065 |
Alt Symbol | GPCR42, GPR172B, PAR2, RBFVD, RFT1, RFVT1, hRFT1 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 52 (riboflavin transporter), member 1 |
Other Description | G protein-coupled receptor 172B|G-protein coupled receptor GPCR42|PERV-A receptor 2|porcine endogenous retrovirus A receptor 2|solute carrier family 52, riboflavin transporter, member 1 |
Swissprots | B5MEV2 Q9NWF4 Q86UT0 Q6P9E0 B5MEV1 |
Accessions | BAB89337 EAW90363 EAW90364 EAW90365 Q9NWF4 AB362533 BAG71128 AB362534 BAG71129 AK000922 BAA91427 AK023570 AK123566 BAG53914 AY070775 AAL59883 BC060810 AAH60810 BC092473 AAH92473 BU752646 DA383729 EU832193 ACE86763 JF432427 ADZ15644 XM_011523951 XP_011522253 NM_001104577 NP_001098047 NM_017986 NP_060456 |
Function | Riboflavin transporter. Riboflavin transport is Na(+)- independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A). {ECO:0000269|PubMed:12740431, ECO:0000269|PubMed:20463145}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:18632736, ECO:0000269|PubMed:20463145}; Multi-pass membrane protein {ECO:0000269|PubMed:18632736, ECO:0000269|PubMed:20463145}. |
Tissue Specificity | Widely expressed. Highly expressed in the testis, placenta and small intestine. Expressed at lower level in other tissues. {ECO:0000269|PubMed:12740431, ECO:0000269|PubMed:18632736, ECO:0000269|PubMed:20463145}. |
GPR172B CRISPR/Cas9 KO Plasmid (h) - sc-407324 from Santa Cruz Biotechnology
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GPR172B HDR Plasmid (h) - sc-407324-HDR from Santa Cruz Biotechnology
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GPR172B Double Nickase Plasmid (h) - sc-407324-NIC from Santa Cruz Biotechnology
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GPR172B Double Nickase Plasmid (h2) - sc-407324-NIC-2 from Santa Cruz Biotechnology
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GPR172B CRISPR Activation Plasmid (h) - sc-407324-ACT from Santa Cruz Biotechnology
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GPR172B CRISPR Activation Plasmid (h2) - sc-407324-ACT-2 from Santa Cruz Biotechnology
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GPR172B Lentiviral Activation Particles (h) - sc-407324-LAC from Santa Cruz Biotechnology
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GPR172B Lentiviral Activation Particles (h2) - sc-407324-LAC-2 from Santa Cruz Biotechnology
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GPR172B siRNA (h) - sc-93922 from Santa Cruz Biotechnology
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GPR172B shRNA Plasmid (h) - sc-93922-SH from Santa Cruz Biotechnology
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GPR172B shRNA (h) Lentiviral Particles - sc-93922-V from Santa Cruz Biotechnology
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GPR172B RNAi - H00055065-R02 from Novus Biologicals
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MISSION® esiRNA - EHU080451 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9583 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9583 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01693 from Sigma-Aldrich
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SLC52A1 siRNA (Human) - CRJ0441 from Cohesion Biosciences
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SLC52A1 - MBS8240786 from MyBioSource
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shRNA set against Human GPR172B (NM_017986.3) - SHH306562 from Creative biogene
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shRNA set against Human GPR172B(NM_017986.3) - SHH098999 from Creative biogene
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Human SLC52A1 siRNA - orb270942 from Biorbyt
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SLC52A1 shRNA Plasmid (Human) - CHJ0441 from Cohesion Biosciences
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SLC52A1 miRNA 3'UTR clone - MiUTR1H-04201 from Creative biogene
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SLC52A1 miRNA 3'UTR clone - MiUTR3H-09534 from Creative biogene
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