Gene Symbol | Trpm2 |
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Entrez Gene | 28240 |
Alt Symbol | 9830168K16Rik, C79133, LTRPC2, TRPC7, Trp7, Trrp7 |
Species | Mouse |
Gene Type | protein-coding |
Description | transient receptor potential cation channel, subfamily M, member 2 |
Other Description | LTrpC-2|long transient receptor potential channel 2|transient receptor potential cation channel subfamily M member 2|transient receptor potential channel 7|transient receptor protein 7 |
Swissprots | Q91YD4 |
Accessions | EDL31767 EDL31768 Q91YD4 AB166747 BAD83707 AJ344343 CAC69081 AJ878415 CAI47592 AK034099 AK036731 AK039405 AK134735 BAE22263 AK136905 BC118920 BC141391 AAI41392 CJ108999 XM_006513729 XP_006513792 XM_006513730 XP_006513793 XM_006513731 XP_006513794 XM_006513732 XP_006513795 XM_006513733 XP_006513796 XM_011243470 XP_011241772 XR_871714 NM_138301 NP_612174 |
Function | Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Has ADP-ribose pyrophosphatase activity (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane {ECO:0000269|PubMed:11804595}; Multi-pass membrane protein {ECO:0000269|PubMed:11804595}. |
Tissue Specificity | Widely expressed, with highest levels in lung, spleen, eye and brain. {ECO:0000269|PubMed:11804595}. |
Top Pathways | Oxytocin signaling pathway |
TRPM2 Antibody - NB110-81601 from Novus Biologicals
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TRPM2 Antibody - NB110-82364 from Novus Biologicals
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TRPM2 Antibody [Alexa Fluor (R) 700] - NB110-81601AF700 from Novus Biologicals
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TRPM2 Antibody [Alexa Fluor (R) 647] - NB110-81601AF647 from Novus Biologicals
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TRPM2 Antibody [Alexa Fluor (R) 488] - NB110-81601AF488 from Novus Biologicals
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TRPM2 Antibody [Alexa Fluor (R) 405] - NB110-81601AF405 from Novus Biologicals
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TRPM2 Antibody [FITC] - NB110-81601F from Novus Biologicals
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TRPM2 Antibody [DyLight 405] - NB110-81601V from Novus Biologicals
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TRPM2 Antibody [DyLight 650] - NB110-81601C from Novus Biologicals
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TRPM2 Antibody [DyLight 550] - NB110-81601R from Novus Biologicals
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TRPM2 Antibody [DyLight 488] - NB110-81601G from Novus Biologicals
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TRPM2 Antibody [Biotin] - NB110-81601B from Novus Biologicals
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TRPM2 Antibody [HRP] - NB110-81601H from Novus Biologicals
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TRPM2 Antibody [Alexa Fluor (R) 700] - NB110-82364AF700 from Novus Biologicals
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TRPM2 Antibody [Alexa Fluor (R) 647] - NB110-82364AF647 from Novus Biologicals
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TRPM2 Antibody [Alexa Fluor (R) 488] - NB110-82364AF488 from Novus Biologicals
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TRPM2 Antibody [Alexa Fluor (R) 405] - NB110-82364AF405 from Novus Biologicals
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TRPM2 Antibody [DyLight 550] - NB110-82364R from Novus Biologicals
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TRPM2 Antibody [DyLight 488] - NB110-82364G from Novus Biologicals
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TRPM2 Antibody [HRP] - NB110-82364H from Novus Biologicals
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TRPM2 Antibody [DyLight 650] - NB110-82364C from Novus Biologicals
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TRPM2 Antibody [Biotin] - NB110-82364B from Novus Biologicals
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TRPM2 Antibody [FITC] - NB110-82364F from Novus Biologicals
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TRPM2 Antibody [DyLight 405] - NB110-82364V from Novus Biologicals
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TRPM2-Antibody - AG1344 from Abgent, a WuXi AppTec company
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