| Gene Symbol |
Trpm2
|
| Entrez Gene |
28240
|
| Alt Symbol |
9830168K16Rik, C79133, LTRPC2, TRPC7, Trp7, Trrp7
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily M, member 2
|
| Other Description |
LTrpC-2|long transient receptor potential channel 2|transient receptor potential cation channel subfamily M member 2|transient receptor potential channel 7|transient receptor protein 7
|
| Swissprots |
Q91YD4
|
| Accessions |
EDL31767 EDL31768 Q91YD4 AB166747 BAD83707 AJ344343 CAC69081 AJ878415 CAI47592 AK034099 AK036731 AK039405 AK134735 BAE22263 AK136905 BC118920 BC141391 AAI41392 CJ108999 XM_006513729 XP_006513792 XM_006513730 XP_006513793 XM_006513731 XP_006513794 XM_006513732 XP_006513795 XM_006513733 XP_006513796 XM_011243470 XP_011241772 XR_871714 NM_138301 NP_612174
|
| Function |
Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Has ADP-ribose pyrophosphatase activity (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:11804595}; Multi-pass membrane protein {ECO:0000269|PubMed:11804595}.
|
| Tissue Specificity |
Widely expressed, with highest levels in lung, spleen, eye and brain. {ECO:0000269|PubMed:11804595}.
|
| Top Pathways |
Oxytocin signaling pathway
|