| Gene Symbol |
Ggt1
|
| Entrez Gene |
116568
|
| Alt Symbol |
GGLUT, Ggt, Ggtp
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
gamma-glutamyltransferase 1
|
| Other Description |
GGT 1|gamma glutamyl-transferase 1|gamma-glutamyl transpeptidase|gamma-glutamyltranspeptidase 1|glutathione hydrolase 1|leukotriene-C4 hydrolase
|
| Swissprots |
Q63218 Q6AZ32 Q63217 P07314
|
| Accessions |
AAA41217 EDL97199 EDL97200 EDL97201 EDL97202 EDL97203 EDL97204 EDL97205 EDL97206 EDL97207 EDL97208 EDL97209 EDL97210 EDL97211 EDL97212 P07314 BC078768 AAH78768 M33821 AAA57295 M33822 AAB59698 X15443 CAA33483 NM_053840 NP_446292
|
| Function |
Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide, cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Detected in adult kidney and mammary gland, and in fetal liver.
|
| Top Pathways |
Taurine and hypotaurine metabolism, Glutathione metabolism, Arachidonic acid metabolism, Cyanoamino acid metabolism
|