| Gene Symbol | CHST3 |
|---|---|
| Entrez Gene | 9469 |
| Alt Symbol | C6ST, C6ST1, HSD |
| Species | Human |
| Gene Type | protein-coding |
| Description | carbohydrate (chondroitin 6) sulfotransferase 3 |
| Other Description | C6ST-1|GST-0|carbohydrate sulfotransferase 3|chondroitin 6-O-sulfotransferase 1|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0 |
| Swissprots | O75099 Q52M30 Q7LGC8 |
| Accessions | EAW54440 Q7LGC8 AB012192 BAA32576 AB017915 BAA36348 AI041015 AK025251 BC033183 BC093690 AAH93690 BC104856 AAI04857 BG325090 DA223095 DB289525 XM_006718075 XP_006718138 XM_011540369 XP_011538671 NM_004273 NP_004264 |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N- acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen. {ECO:0000269|PubMed:9714738, ECO:0000269|PubMed:9883891}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Widely expressed in adult tissues. Expressed in heart, placenta, skeletal muscle and pancreas. Also expressed in various immune tissues such as spleen, lymph node, thymus and appendix. {ECO:0000269|PubMed:9714738}. |
| Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |