Gene Symbol | CHST3 |
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Entrez Gene | 9469 |
Alt Symbol | C6ST, C6ST1, HSD |
Species | Human |
Gene Type | protein-coding |
Description | carbohydrate (chondroitin 6) sulfotransferase 3 |
Other Description | C6ST-1|GST-0|carbohydrate sulfotransferase 3|chondroitin 6-O-sulfotransferase 1|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0 |
Swissprots | O75099 Q52M30 Q7LGC8 |
Accessions | EAW54440 Q7LGC8 AB012192 BAA32576 AB017915 BAA36348 AI041015 AK025251 BC033183 BC093690 AAH93690 BC104856 AAI04857 BG325090 DA223095 DB289525 XM_006718075 XP_006718138 XM_011540369 XP_011538671 NM_004273 NP_004264 |
Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N- acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen. {ECO:0000269|PubMed:9714738, ECO:0000269|PubMed:9883891}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Tissue Specificity | Widely expressed in adult tissues. Expressed in heart, placenta, skeletal muscle and pancreas. Also expressed in various immune tissues such as spleen, lymph node, thymus and appendix. {ECO:0000269|PubMed:9714738}. |
Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |
Human CHST3 protein fragment - ab160502 from Abcam
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CHST3 Antibody Blocking Peptide - LS-E226 from LifeSpan Bioscience
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Recombinant Human Carbohydrate Sulfotransferase 3/CHST3 Protein - H00009469-Q01 from Novus Biologicals
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CHST3-Antibody-N-term-Blocking-Peptide - BP10461a from Abgent, a WuXi AppTec company
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Recombinant Human CHST3, CF - 7450-ST-020 from R&D Systems
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CHST3 - H00009469-Q01-10 from Acris Antibodies
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CHST3 - H00009469-Q01-25 from Acris Antibodies
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CHST3 fusion protein - ag13008 from Proteintech Group
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Recombinant Human CHST3, GST-tagged - CHST3-11229H from Creative Biomart
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Recombinant Human CHST3, His-tagged - CHST3-352H from Creative Biomart
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Recombinant Human Carbohydrate sulfotransferase 3(CHST3) - CSB-YP759175HU CSB-EP759175HU CSB-BP759175HU CSB-MP759175HU from Cusabio
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Recombinant Human CHST3 Protein, CF - 7450-ST from R&D Systems
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Carbohydrate sulfotransferase 3 (CHST3), Recombinant Protein - MBS1112163 from MyBioSource
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CHST3 Peptide, Human - M34GP03152H from Creative Peptides
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Carbohydrate Sulfotransferase 3/CHST3 Recombinant Protein Antigen - NBP2-31611PEP from Novus Biologicals
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Carbohydrate sulfotransferase 3, Recombinant Protein - MBS7042560 from MyBioSource
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Recombinant Mouse CHST3 Protein, CF - 5356-ST from Novus Biologicals
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