| Gene Symbol |
ACMSD
|
| Entrez Gene |
130013
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
aminocarboxymuconate semialdehyde decarboxylase
|
| Other Description |
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase|picolinate carboxylase
|
| Swissprots |
Q8TDX5 Q96KY2 Q3B7X3 Q53SR5
|
| Accessions |
AAY14997 EAX11649 EAX11650 EAX11651 EAX11652 Q8TDX5 AB071418 BAB86938 AK125008 BAC86023 BC016018 AAH16018 BC107420 AAI07421 BG428338 XM_005263586 XP_005263643 XM_005263587 XP_005263644 XM_005263588 XP_005263645 XM_005263589 XP_005263646 XM_005263590 XP_005263647 XM_011510592 XP_011508894 NM_001307983 NP_001294912 NM_138326 NP_612199
|
| Function |
Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. {ECO:0000269|PubMed:19843166}.
|
| Top Pathways |
Tryptophan metabolism
|