Gene Symbol | CHST1 |
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Entrez Gene | 8534 |
Alt Symbol | C6ST, GST-1, KS6ST, KSGal6ST, KSST |
Species | Human |
Gene Type | protein-coding |
Description | carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 |
Other Description | carbohydrate (chondroitin 6/keratan) sulfotransferase 1|carbohydrate sulfotransferase 1|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1 |
Swissprots | D3DQP2 O43916 |
Accessions | AAP88041 EAW68034 EAW68035 EAW68036 EAW68037 EAW68038 EAW68039 O43916 AB003791 BAA24840 AF090137 AAD19878 AI793094 AK311168 BC022567 AAH22567 BC028235 AAH28235 BI917296 DA193787 DB493321 U65637 AAC28776 XM_006718356 XP_006718419 XR_428858 NM_003654 NP_003645 |
Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N- acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. {ECO:0000269|PubMed:10330415, ECO:0000269|PubMed:10642612}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Tissue Specificity | Widely expressed at low level. Expressed in brain and skeletal muscle. Expressed by high endothelial cells (HEVs) and leukocytes. {ECO:0000269|PubMed:11310842, ECO:0000269|PubMed:9405439}. |
Top Pathways | Glycosaminoglycan biosynthesis - keratan sulfate |
Human Keratan Sulfate protein fragment - ab152884 from Abcam
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CHST1 Antibody Blocking Peptide - LS-E16624 from LifeSpan Bioscience
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CHST1 Antibody Blocking Peptide - LS-E16623 from LifeSpan Bioscience
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Recombinant Human Carbohydrate Sulfotransferase 1/CHST1/KS6ST Protein - H00008534-Q01 from Novus Biologicals
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Recombinant Human CHST1, CF - 5316-ST-020 from R&D Systems
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CHST1 Blocking Peptide - 33R-10227 from Fitzgerald
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CHST1 Blocking Peptide - 33R-8443 from Fitzgerald
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CHST1 Blocking Peptide - abx063489 from Abbexa
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CHST1 - H00008534-Q01-10 from Acris Antibodies
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CHST1 - H00008534-Q01-25 from Acris Antibodies
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CHST1 fusion protein - Ag3183 from Proteintech Group
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Recombinant Human CHST1, GST-tagged - CHST1-11222H from Creative Biomart
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Recombinant Human CHST1, His-tagged - CHST1-539H from Creative Biomart
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CHST1 Blocking Peptide - CBP2295 from Cohesion Biosciences
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CHST1 Peptide - BS5662P from Bioworld Technology
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Recombinant Human Carbohydrate sulfotransferase 1(CHST1) - CSB-YP005402HU CSB-EP005402HU CSB-BP005402HU CSB-MP005402HU from Cusabio
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Recombinant Human CHST1 Protein, CF - 5316-ST from R&D Systems
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Carbohydrate sulfotransferase 1 (CHST1), Recombinant Protein - MBS1154708 from MyBioSource
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CHST1-Blocking-Peptide-C-term - BP21231b from Abgent, a WuXi AppTec company
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CHST1 Peptide, Human - M34GP03144H from Creative Peptides
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Carbohydrate sulfotransferase 1, Recombinant Protein - MBS7042555 from MyBioSource
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Recombinant Human CHST1 Protein, CF - 5316-ST from Novus Biologicals
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