CHST1

Gene Symbol CHST1
Entrez Gene 8534
Alt Symbol C6ST, GST-1, KS6ST, KSGal6ST, KSST
Species Human
Gene Type protein-coding
Description carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
Other Description carbohydrate (chondroitin 6/keratan) sulfotransferase 1|carbohydrate sulfotransferase 1|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1
Swissprots D3DQP2 O43916
Accessions AAP88041 EAW68034 EAW68035 EAW68036 EAW68037 EAW68038 EAW68039 O43916 AB003791 BAA24840 AF090137 AAD19878 AI793094 AK311168 BC022567 AAH22567 BC028235 AAH28235 BI917296 DA193787 DB493321 U65637 AAC28776 XM_006718356 XP_006718419 XR_428858 NM_003654 NP_003645
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N- acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. {ECO:0000269|PubMed:10330415, ECO:0000269|PubMed:10642612}.
Subcellular Location Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue Specificity Widely expressed at low level. Expressed in brain and skeletal muscle. Expressed by high endothelial cells (HEVs) and leukocytes. {ECO:0000269|PubMed:11310842, ECO:0000269|PubMed:9405439}.
Top Pathways Glycosaminoglycan biosynthesis - keratan sulfate

Human Keratan Sulfate protein fragment - ab152884 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE analysis of ab152884 stained with Coomassie Blue.

CHST1 Antibody Blocking Peptide - LS-E16624 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CHST1 Antibody Blocking Peptide - LS-E16623 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human Carbohydrate Sulfotransferase 1/CHST1/KS6ST Protein - H00008534-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Recombinant Human CHST1, CF - 5316-ST-020 from R&D Systems

Category Protein
Source Chinese Hamster Ovary cell line, CHO-derived, Arg24-Ser411, with an N-terminal 6-His tag

CHST1 Blocking Peptide - 33R-10227 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

CHST1 Blocking Peptide - 33R-8443 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

CHST1 Blocking Peptide - abx063489 from Abbexa

Category Peptide
Species Human, Mouse, Rat, Bovine, Dog

CHST1 - H00008534-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

CHST1 - H00008534-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

CHST1 fusion protein - Ag3183 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

Recombinant Human CHST1, GST-tagged - CHST1-11222H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human CHST1, His-tagged - CHST1-539H from Creative Biomart

Category Protein
Source CHO Cells
Species Human

CHST1 Blocking Peptide - CBP2295 from Cohesion Biosciences

Category Peptide
Prices $100.00, $300.00
Sizes 1 mg, 5 mg
Species Human, Mouse, Rat, Bovine, Dog

CHST1 Peptide - BS5662P from Bioworld Technology

Category Peptide
Prices $158.00
Sizes 100 µl

Recombinant Human Carbohydrate sulfotransferase 1(CHST1) - CSB-YP005402HU CSB-EP005402HU CSB-BP005402HU CSB-MP005402HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Recombinant Human CHST1 Protein, CF - 5316-ST from R&D Systems

Category Protein
Prices $329.00
Sizes 20 µg
Source Chinese Hamster Ovary cell line, CHO-derived Arg24-Ser411, with an N-terminal 6-His tag
Species Human

Carbohydrate sulfotransferase 1 (CHST1), Recombinant Protein - MBS1154708 from MyBioSource

Category Protein
Prices $1,905.00, $1,905.00, $2,370.00, $2,370.00
Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

CHST1-Blocking-Peptide-C-term - BP21231b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CHST1 Peptide, Human - M34GP03144H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Carbohydrate sulfotransferase 1, Recombinant Protein - MBS7042555 from MyBioSource

Category Protein
Prices $1,215.00, $2,200.00, $3,410.00
Sizes 10 µg, 50 µg, 100 µg
Source Cell Free Expression
Species Human

Recombinant Human CHST1 Protein, CF - 5316-ST from Novus Biologicals

Category Protein
Prices $329.00
Sizes 20 µg
Species Human
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