CHST1

Gene Symbol CHST1
Entrez Gene 8534
Alt Symbol C6ST, GST-1, KS6ST, KSGal6ST, KSST
Species Human
Gene Type protein-coding
Description carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
Other Description carbohydrate (chondroitin 6/keratan) sulfotransferase 1|carbohydrate sulfotransferase 1|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1
Swissprots D3DQP2 O43916
Accessions AAP88041 EAW68034 EAW68035 EAW68036 EAW68037 EAW68038 EAW68039 O43916 AB003791 BAA24840 AF090137 AAD19878 AI793094 AK311168 BC022567 AAH22567 BC028235 AAH28235 BI917296 DA193787 DB493321 U65637 AAC28776 XM_006718356 XP_006718419 XR_428858 NM_003654 NP_003645
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N- acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. {ECO:0000269|PubMed:10330415, ECO:0000269|PubMed:10642612}.
Subcellular Location Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue Specificity Widely expressed at low level. Expressed in brain and skeletal muscle. Expressed by high endothelial cells (HEVs) and leukocytes. {ECO:0000269|PubMed:11310842, ECO:0000269|PubMed:9405439}.
Top Pathways Glycosaminoglycan biosynthesis - keratan sulfate

CHST1 CRISPR/Cas9 KO Plasmid (h) - sc-403978 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHST1 HDR Plasmid (h) - sc-403978-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHST1 Double Nickase Plasmid (h) - sc-403978-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHST1 Double Nickase Plasmid (h2) - sc-403978-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHST1 CRISPR Activation Plasmid (h) - sc-403978-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHST1 CRISPR Activation Plasmid (h2) - sc-403978-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHST1 Lentiviral Activation Particles (h) - sc-403978-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHST1 Lentiviral Activation Particles (h2) - sc-403978-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHST1 siRNA (h) - sc-62110 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CHST1 shRNA Plasmid (h) - sc-62110-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CHST1 shRNA (h) Lentiviral Particles - sc-62110-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN6103 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6103 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CHST1 siRNA (Human) - CRH5605 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CHST1 - MBS8210411 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CHST1 (NM_003654.5) - SHH263705 from Creative biogene

Category siRNA
Species Reactivities Human

Human CHST1 siRNA - orb266107 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CHST1 shRNA Plasmid (Human) - CHH5605 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CHST1 miRNA 3'UTR clone - MiUTR3H-06280 from Creative biogene

Species Reactivities Human
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