Gene Symbol | SLC38A3 |
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Entrez Gene | 10991 |
Alt Symbol | G17, NAT1, SN1, SNAT3 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 38, member 3 |
Other Description | N-system amino acid transporter 1|Na(+)-coupled neutral amino acid transporter 3|sodium-coupled neutral amino acid transporter 3|system N amino acid transporter 1|system N1 Na+ and H+-coupled glutamine transporter |
Swissprots | Q6IB34 Q99624 B2R8Q0 |
Accessions | EAW65049 EAW65050 Q99624 AF244548 AAG15313 AK293801 BAH11599 AK299677 BAH13100 AK313461 BAG36247 AM392752 CAL37630 AM393543 CAL38420 BC042875 AAH42875 BM662099 BP362985 BX537382 CAD97624 CR456970 CAG33251 U49082 AAB47236 XM_006712954 XP_006713017 NM_006841 NP_006832 |
Function | Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission. {ECO:0000250|UniProtKB:Q9JHZ9, ECO:0000269|PubMed:10823827}. |
Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Top Pathways | Proximal tubule bicarbonate reclamation, GABAergic synapse, Glutamatergic synapse |
SNAT3 CRISPR/Cas9 KO Plasmid (h) - sc-403696 from Santa Cruz Biotechnology
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SNAT3 HDR Plasmid (h) - sc-403696-HDR from Santa Cruz Biotechnology
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SNAT3 Double Nickase Plasmid (h) - sc-403696-NIC from Santa Cruz Biotechnology
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SNAT3 Double Nickase Plasmid (h2) - sc-403696-NIC-2 from Santa Cruz Biotechnology
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SNAT3 CRISPR Activation Plasmid (h) - sc-403696-ACT from Santa Cruz Biotechnology
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SNAT3 CRISPR Activation Plasmid (h2) - sc-403696-ACT-2 from Santa Cruz Biotechnology
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SNAT3 Lentiviral Activation Particles (h) - sc-403696-LAC from Santa Cruz Biotechnology
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SNAT3 Lentiviral Activation Particles (h2) - sc-403696-LAC-2 from Santa Cruz Biotechnology
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SNAT3 siRNA (h) - sc-44980 from Santa Cruz Biotechnology
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SNAT3 shRNA Plasmid (h) - sc-44980-SH from Santa Cruz Biotechnology
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SNAT3 shRNA (h) Lentiviral Particles - sc-44980-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU016211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19607 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19607 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06994 from Sigma-Aldrich
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SLC38A3 siRNA (Human) - CRH7506 from Cohesion Biosciences
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SLC38A3 RNAi - H00010991-R01 from Novus Biologicals
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SLC38A3 - MBS8233776 from MyBioSource
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shRNA set against Human SLC38A3 (NM_006841.4) - SHH410968 from Creative biogene
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shRNA set against Human SLC38A3(NM_006841.4) - SHL007766 from Creative biogene
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SLC38A3 shRNA Plasmid (Human) - CHH7506 from Cohesion Biosciences
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SLC38A3 miRNA 3'UTR clone - MiUTR1H-09554 from Creative biogene
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