| Gene Symbol |
SDCCAG3
|
| Entrez Gene |
10807
|
| Alt Symbol |
NY-CO-3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serologically defined colon cancer antigen 3
|
| Other Description |
antigen NY-CO-3
|
| Swissprots |
Q5SXN8 Q5SXN4 Q5SXN3 A6NCP1 Q6V704 Q96C92 Q9NVY5 O60525 Q5SXN1 Q5SXN2
|
| Accessions |
EAW88228 EAW88229 EAW88230 EAW88231 Q96C92 AA742964 AF039688 AAC18037 AK001296 BAA91607 AL559847 AY129014 AAM98757 AY349357 AAQ56721 BC014515 AAH14515 BM549484 BQ723499 DQ893083 ABM84009 DQ896349 ABM87348 XM_005266050 XP_005266107 XM_005266051 XP_005266108 XM_011518156 XP_011516458 XM_011518157 XP_011516459 XR_929704 NM_001039707 NP_001034796 NM_001039708 NP_001034797 NM_006643 NP_006634
|
| Function |
May be involved in modulation of TNF response. May be involved in presentation of TNFRSF1A on the cell surface (By similarity). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400). {ECO:0000250|UniProtKB:A2AIW0, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25278552}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250|UniProtKB:A2AIW0}. Midbody {ECO:0000269|PubMed:23108400}. Early endosome {ECO:0000269|PubMed:23108400}. Recycling endosome {ECO:0000269|PubMed:23108400}. Note=During cytokinesis colocalized with PTPN13 at the midbody (PubMed:23108400). Colocalizes in a FAM21-dependent manner with the retromer CSC complex at endosomes (PubMed:25278552).
|
![Western Blot: SDCCAG3 Overexpression Lysate (Adult Normal) [NBL1-15763] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SDCCAG3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3956_SDCCAG3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15763-img0002.jpg)