| Gene Symbol |
KRTAP3-3
|
| Entrez Gene |
85293
|
| Alt Symbol |
KAP3.3, KRTAP3.3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
keratin associated protein 3-3
|
| Other Description |
high sulfur keratin-associated protein 3.3|keratin-associated protein 3-3|keratin-associated protein 3.3
|
| Swissprots |
Q6NTD4 Q9BYR6 Q52LP0
|
| Accessions |
EAW60693 Q9BYR6 AJ406933 CAC27572 BC069099 AAH69099 BC069448 AAH69448 BC093845 AAH93845 BC093847 AAH93847 HQ448442 ADQ32922 NM_033185 NP_149441
|
| Function |
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
|
| Tissue Specificity |
Localized to the upper cortex of the hair shaft. {ECO:0000269|PubMed:11279113}.
|