Notch1

Gene Symbol Notch1
Entrez Gene 18128
Alt Symbol 9930111A19Rik, Mis6, N1, Tan1, lin-12
Species Mouse
Gene Type protein-coding
Description notch 1
Other Description Motch A|Notch gene homolog 1|mT14|major type A protein|neurogenic locus notch homolog protein 1|p300|transmembrane receptor Notch1
Swissprots Q9QW58 Q99JC2 Q8K428 Q7TQ52 Q9R0X7 Q3TZW2 Q06007 Q01705 Q3U3Y2 Q7TQ50 Q61905 Q7TQ51
Accessions BAC77038 BAC77039 BAC77040 CAL48809 EDL08321 Q01705 AB101624 AB101625 AB101626 AB101627 AB101628 AB101629 AB101630 AB101631 AB101632 AB101633 AB101634 AB101636 AB101637 AF508809 AAM28905 AJ238029 CAB40733 AK004408 AK042197 BAC31194 AK054089 AK079454 AK090118 AK149054 AK154528 BAE32653 AK157475 BAE34095 AK157979 AK171329 BC010325 BC058427 BC138441 AAI38442 BC138442 AAI38443 BF318436 BY233933 L02613 AAK14898 X68278 CAA48339 X82562 CAA57909 Z11886 CAA77941 Z21925 NM_008714 NP_032740
Function Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Highly expressed in the brain, lung and thymus. Expressed at lower levels in the spleen, bone-marrow, spinal cord, eyes, mammary gland, liver, intestine, skeletal muscle, kidney and heart. In the hair follicle, highly expressed exclusively in the epithelial compartment. {ECO:0000269|PubMed:15965470}.
Top Pathways Notch signaling pathway, Prion diseases, MicroRNAs in cancer, Dorso-ventral axis formation

Recombinant Mouse Notch-1 Fc Chimera, CF - 5267-TK-050 from R&D Systems

Category Protein
Source Chinese Hamster Ovary cell line, CHO-derived

Mouse Notch-1 (Fc Tag) protein - orb232618 from Biorbyt

Category Protein
Prices $400.00, $816.00
Sizes 50 μg, 200 μg
Species Mouse

Mouse Notch-1 protein (His Tag) - orb139402 from Biorbyt

Category Protein
Prices $400.00, $612.00
Sizes 50 μg, 100 μg
Source Baculovirus-Insect Cells
Species Mouse
SDS-PAGE analysis of Mouse Notch-1 protein (His Tag)

Notch1 fusion protein - Ag0107 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Mouse

Recombinant Mouse Notch1, Fc Chimera - Notch1-400M from Creative Biomart

Category Protein
Source CHO cells
Species Mouse

Recombinant Mouse Notch1, Fc-tagged - Notch1-435M from Creative Biomart

Category Protein
Source CHO Cells
Species Mouse

Notch-1, mouse recombinant - 7530-25 from Biovision

Category Protein
Prices $225.00
Sizes 25 μg
Source CHO cells
Species Mouse

Recombinant Mouse Notch-1 Fc Chimera Protein, CF - 5267-TK from R&D Systems

Category Protein
Prices $329.00
Sizes 50 µg
Source Chinese Hamster Ovary cell line, CHO-derived Mouse Notch-1 (Ala19 - Gln526) Accession # AAM28905 IEGRMDP Mouse IgG 2A (Glu98 - Lys330) N-terminus C-terminus
Species Mouse

Notch 1, Peptide - MBS843945 from MyBioSource

Category Peptide
Prices $165.00
Sizes 50 µg

Recombinant Mouse Notch-1 / NOTCH1 Protein (His tag) - PKSM040558 from Elabscience

Category Protein
Source Baculovirus-Insect Cells
Species Mouse

Recombinant Mouse Notch1 protein, His-tagged - Notch1-422M from Creative Biomart

Category Protein
Source Insect cells
Species Mouse

Recombinant Mouse Notch1 protein, Fc-tagged - Notch1-423M from Creative Biomart

Category Protein
Source CHO
Species Mouse

Mouse-Notch1-Blocking-Peptide-C-term - BP21349b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg
Species Mouse

Notch1 Antibody - SH-A14071 from Novatein Biosciences

Prices $315.00
Sizes 100 µl
Species Human, Mouse, Rat

Notch-1, mouse recombinant - 7530 from Biovision

Category Protein
Prices $235.00
Sizes 25 μg
Source CHO cells
Species Mouse

Mouse Notch-1 / NOTCH1 Protein (ECD,Fc Tag) - 50654-M02S from ABclonal

Category Protein
Prices $178.00, $448.00
Sizes 50 µg, 200 µg
Source CHO Stable Cells
Species Mouse

Mouse Notch-1 / NOTCH1 Protein (His Tag) - 50654-M08B from ABclonal

Category Protein
Prices $178.00, $298.00
Sizes 50 µg, 100 µg
Source Baculovirus-Insect Cells
Species Mouse

Notch1 Recombinant Protein - 90-291 from ProSci

Category Protein
Prices $375.00
Sizes 50 µg
Source CHO cells
Species Mouse

Notch-1, Mouse recombinant - 268-11119-1 from RayBiotech

Category Protein
Species Mouse

Notch-1, Recombinant Protein - MBS845034 from MyBioSource

Category Protein
Prices $280.00
Sizes 25 µg
Source CHO Cells

Notch-1 / NOTCH1, Recombinant Protein - MBS2546860 from MyBioSource

Category Protein
Prices $475.00, $775.00
Sizes 50 µg, 100 µg
Source Baculovirus-Insect Cells
Search more