Gene Symbol | GC |
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Entrez Gene | 2638 |
Alt Symbol | DBP, DBP/GC, GRD3, HEL-S-51, VDBG, VDBP |
Species | Human |
Gene Type | protein-coding |
Description | group-specific component (vitamin D binding protein) |
Other Description | VDB|epididymis secretory protein Li 51|gc-globulin|vitamin D-binding alpha-globulin|vitamin D-binding protein |
Swissprots | Q16310 P02774 Q6GTG1 Q53F31 Q16309 D6RAK8 B4DPP2 |
Accessions | AAA19662 AAA61704 AAB29423 AAD13872 AAD14249 AAD14250 AJS18493 EAX05645 P02774 AA702473 AK223458 BAD97178 AK290827 BAF83516 AK298433 BAG60654 AK309595 AK312971 AK315853 BAF98744 BC022310 BC057228 AAH57228 BX494962 EU794674 ACJ13728 X03178 CAA26938 XM_006714177 XP_006714240 NM_000583 NP_000574 NM_001204306 NP_001191235 NM_001204307 NP_001191236 |
Function | Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes. |
Subcellular Location | Secreted. |
DBP CRISPR/Cas9 KO Plasmid (h) - sc-403069 from Santa Cruz Biotechnology
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DBP HDR Plasmid (h) - sc-403069-HDR from Santa Cruz Biotechnology
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DBP Double Nickase Plasmid (h) - sc-403069-NIC from Santa Cruz Biotechnology
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DBP Double Nickase Plasmid (h2) - sc-403069-NIC-2 from Santa Cruz Biotechnology
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DBP CRISPR Activation Plasmid (h) - sc-403069-ACT from Santa Cruz Biotechnology
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DBP CRISPR Activation Plasmid (h2) - sc-403069-ACT-2 from Santa Cruz Biotechnology
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DBP Lentiviral Activation Particles (h) - sc-403069-LAC from Santa Cruz Biotechnology
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DBP Lentiviral Activation Particles (h2) - sc-403069-LAC-2 from Santa Cruz Biotechnology
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DBP siRNA (h) - sc-41375 from Santa Cruz Biotechnology
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DBP shRNA Plasmid (h) - sc-41375-SH from Santa Cruz Biotechnology
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DBP shRNA (h) Lentiviral Particles - sc-41375-V from Santa Cruz Biotechnology
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Vitamin D BP RNAi - H00002638-R01 from Novus Biologicals
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MISSION® esiRNA - EHU011421 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9177 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9177 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00505 from Sigma-Aldrich
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GC siRNA (Human) - CRH1753 from Cohesion Biosciences
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GC - MBS8228109 from MyBioSource
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GC shRNA Plasmid (Human) - CHH1753 from Cohesion Biosciences
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GC miRNA 3'UTR clone - MiUTR3H-00961 from Creative biogene
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