Gene Symbol | CLDN8 |
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Entrez Gene | 9073 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | claudin 8 |
Other Description | claudin-8 |
Swissprots | D3DSE3 Q53EX7 P56748 |
Accessions | BAA95567 CAB60615 CAI93554 EAX09901 EAX09902 P56748 AK022269 BAG51070 AK223512 BAD97232 AL049977 AW235670 AY358707 AAQ89070 BC020866 AAH20866 BC058004 AAH58004 DA629490 DQ892002 ABM82928 DQ895192 ABM86118 NM_199328 NP_955360 NM_012132 |
Function | Plays a major role in tight junction-specific obliteration of the intercellular space. {ECO:0000250}. |
Subcellular Location | Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Localizes to tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal cells, and in the corpus at the interface between basal and principal cells. |
Tissue Specificity | Expressed in the epididymis, mainly in the caput segment. {ECO:0000269|PubMed:17287494}. |
Top Pathways | Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Hepatitis C |
claudin-8 CRISPR/Cas9 KO Plasmid (h) - sc-404251 from Santa Cruz Biotechnology
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claudin-8 HDR Plasmid (h) - sc-404251-HDR from Santa Cruz Biotechnology
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claudin-8 Double Nickase Plasmid (h) - sc-404251-NIC from Santa Cruz Biotechnology
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claudin-8 Double Nickase Plasmid (h2) - sc-404251-NIC-2 from Santa Cruz Biotechnology
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claudin-8 CRISPR Activation Plasmid (h) - sc-404251-ACT from Santa Cruz Biotechnology
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claudin-8 CRISPR Activation Plasmid (h2) - sc-404251-ACT-2 from Santa Cruz Biotechnology
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claudin-8 Lentiviral Activation Particles (h) - sc-404251-LAC from Santa Cruz Biotechnology
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claudin-8 Lentiviral Activation Particles (h2) - sc-404251-LAC-2 from Santa Cruz Biotechnology
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claudin-8 siRNA (h) - sc-44865 from Santa Cruz Biotechnology
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claudin-8 shRNA Plasmid (h) - sc-44865-SH from Santa Cruz Biotechnology
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claudin-8 shRNA (h) Lentiviral Particles - sc-44865-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU037051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6192 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6192 from Sigma-Aldrich
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CLDN8 siRNA (Human) - CRH5989 from Cohesion Biosciences
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CLDN8 - MBS8215229 from MyBioSource
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shRNA set against Human CLDN8 (NM_199328.2) - SHH264845 from Creative biogene
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Human CLDN8 siRNA - orb266491 from Biorbyt
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CLDN8 shRNA Plasmid (Human) - CHH5989 from Cohesion Biosciences
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CLDN8 miRNA 3'UTR clone - MiUTR3H-11736 from Creative biogene
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