CHMP4A

Gene Symbol	CHMP4A
Entrez Gene	29082
Alt Symbol	C14orf123, CHMP4, CHMP4B, HSPC134, SHAX2, SNF7, SNF7-1, VPS32-1, VPS32A
Species	Human
Gene Type	protein-coding
Description	charged multivesicular body protein 4A
Other Description	SNF7 homolog associated with Alix-2|Snf7 homologue associated with Alix 2|charged multivesicular body protein 4a|chromatin modifying protein 4A|vacuolar protein sorting-associated protein 32-1
Swissprots	Q9P026 Q86SZ8 Q32Q79 Q9BY43 Q96QJ9 Q14D22
Accessions	EAW66065 EAW66066 EAW66067 EAW66068 Q9BY43 AB100262 BAC79376 AF161483 AAF29098 AF212243 AAK14928 AW732226 AY329084 AAQ91193 BC010893 AAH10893 BC107699 AAI07700 BC113533 AAI13534 BC113535 AAI13536 BC143834 BM041056 CB241867 HQ258138 ADR82892 NM_014169 NP_054888
Function	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities,
Subcellular Location	Cytoplasmic vesicle membrane. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Membrane-associated. Localizes to large vesicle-like structures. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
Tissue Specificity	Widely expressed. Expressed at higher level in heart, kidney, liver and skeletal muscle. Also expressed in brain, placenta, lung and pancreas. {ECO:0000269|PubMed:14678797}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CHMP4A (H-52) - sc-67229 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

CHMP4A (C-15) - sc-49913 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

CHMP4A (P-16) - sc-49915 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

HIF PHD3 (H-59) - sc-98792 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-CHMP4A antibody - ab67058 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-CHMP4A antibody - ab116340 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CHMP4A Antibody - LS-C306949 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-CHMP4A Antibody (C-Terminus) - LS-C145581 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

CHMP4A Antibody - NBP1-79920 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

CHMP4A Antibody - H00029082-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-CHMP4A antibody produced in rabbit - SAB2107670 from Sigma-Aldrich Prices $341.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CHMP4A, (N-terminal) antibody produced in mouse - SAB1407374 from Sigma-Aldrich Prices $347.00 Sizes 50 µg Host Mouse Clonality Polyclonal

CHMP4A antibody - C-terminal region (ARP61976_P050) - ARP61976_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CHMP4A-Antibody-C-term - AP21067a from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

CHMP4A antibody - 70R-10404 from Fitzgerald Prices $345.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

CHMP4A antibody - H00029082-B01P from Acris Antibodies Prices $360.00 Sizes 50 µg Host Mouse Clonality Polyclonal

CHMP4A Antibody - GWB-MW435C from Genway Biotech Prices $368.00 Sizes 50 µg Host Rabbit

CHMP4A, Polyclonal Antibody - MBS648339 from MyBioSource Prices $580.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-CHMP4A Antibody (aa205-239) - LS-C356354 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

CHMP4A Antibody - C-terminal region (OAAB19027) - OAAB19027 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

CHMP4A-antibody-C-terminal-region-AI14754 - AI14754 from Abgent, a WuXi AppTec company Prices $293.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

CHMP4A (E-6) - sc-514869 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

CHMP4A, Polyclonal Antibody - MBS9213680 from MyBioSource Prices $155.00, $340.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

Anti-CHMP4A (full length) polyclonal antibody - CABT-BL1062 from Creative Diagnostics Host Mouse Clonality Polyclonal

Anti-CHMP4A (aa 210-259) polyclonal antibody - CABT-BL1063 from Creative Diagnostics Host Rabbit Clonality Polyclonal

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