CHMP4A

Gene Symbol	CHMP4A
Entrez Gene	29082
Alt Symbol	C14orf123, CHMP4, CHMP4B, HSPC134, SHAX2, SNF7, SNF7-1, VPS32-1, VPS32A
Species	Human
Gene Type	protein-coding
Description	charged multivesicular body protein 4A
Other Description	SNF7 homolog associated with Alix-2|Snf7 homologue associated with Alix 2|charged multivesicular body protein 4a|chromatin modifying protein 4A|vacuolar protein sorting-associated protein 32-1
Swissprots	Q9P026 Q86SZ8 Q32Q79 Q9BY43 Q96QJ9 Q14D22
Accessions	EAW66065 EAW66066 EAW66067 EAW66068 Q9BY43 AB100262 BAC79376 AF161483 AAF29098 AF212243 AAK14928 AW732226 AY329084 AAQ91193 BC010893 AAH10893 BC107699 AAI07700 BC113533 AAI13534 BC113535 AAI13536 BC143834 BM041056 CB241867 HQ258138 ADR82892 NM_014169 NP_054888
Function	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities,
Subcellular Location	Cytoplasmic vesicle membrane. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Membrane-associated. Localizes to large vesicle-like structures. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
Tissue Specificity	Widely expressed. Expressed at higher level in heart, kidney, liver and skeletal muscle. Also expressed in brain, placenta, lung and pancreas. {ECO:0000269|PubMed:14678797}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CHMP4A protein (His tag) - 80R-2118 from Fitzgerald Category Protein Prices $270.00 Sizes 10 µg Source E.coli

CHMP4A (1-265, His-tag) - AR50201PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 50 µg Source E. coli Species Human

CHMP4A (1-265, His-tag) - AR50201PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source E. coli Species Human

CHMP4A - P4906 from Acris Antibodies Category Protein Prices $500.00 Sizes 10 µg Species Human

CHMP4A, 1-265aa, Human, His tag, E.coli - 01-P1376 from ARP American Research Products Category Protein Prices $159.00, $369.00, $849.00 Sizes 2 µg, 10 µg, 50 µg Species Human

CHMP4A fusion protein - Ag18203 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Chromatin Modifying Protein 4A - BP001886-PRO-1024 from Syd Labs Category Protein Prices $160.00, $1,100.00 Sizes 5 µg, 50 µg Source E. coli-derived. Species Human

CHMP4A, 1-265aa, Recombinant Protein - GWB-P0662L from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 10 μg, 50 μg Source E.coli Species Human

Recombinant Human CHMP4A, GST-tagged - CHMP4A-11186H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Charged Multivesicular Body Protein 4A, His-tagged - CHMP4A-1376H from Creative Biomart Category Protein

CHMP4A 1-265aa - CMB-1209 from Reagent Proteins Category Protein Prices $469.00, $889.00 Sizes 10.00 µg, 50.00 µg Source E.coli Species Human

Recombinant Human Charged multivesicular body protein 4a(CHMP4A) - CSB-YP883630HU CSB-EP883630HU CSB-BP883630HU CSB-MP883630HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CHMP4A, 1-265aa, Human, His tag, E.coli - ATGP1376 from ATGen Category Protein Prices $240.00, $720.00 Sizes 10 µg, 50 µg Species Human

CHMP4A - TP322002 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

CHMP4A-Blocking-Peptide-C-term - BP21067a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CHMP4A - PAT-81416-1 from Nordic BioSite Category Protein Species Human

CHMP4A - PAT-81416-2 from Nordic BioSite Category Protein Species Human

Charged multivesicular body protein 4a (CHMP4A), Recombinant Protein - MBS1392349 from MyBioSource Category Protein Prices $975.00, $975.00, $1,195.00, $1,195.00, $1,465.00, $1,465.00, $1,930.00, $1,930.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

CHMP4A, Recombinant Protein - MBS204595 from MyBioSource Category Protein Prices $310.00, $720.00 Sizes 10 µg, 50 µg Source E Coli Species Human

Chromatin Modifying Protein 4A, Recombinant Protein - MBS144847 from MyBioSource Category Protein Prices $140.00, $205.00, $1,125.00 Sizes 1 µg, 5 µg, 50 µg Source E Coli

Search more