Gene Symbol | GRIN3B |
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Entrez Gene | 116444 |
Alt Symbol | GluN3B, NR3B |
Species | Human |
Gene Type | protein-coding |
Description | glutamate receptor, ionotropic, N-methyl-D-aspartate 3B |
Other Description | N-methyl-D-aspartate receptor subtype 3B|NMDA receptor subunit 3B|NMDA type glutamate receptor subunit NR3B|NMDAR3B|glutamate [NMDA] receptor subunit 3B|glutamate receptor ionotropic, NMDA 3B |
Swissprots | Q5EAK7 Q7RTW9 O60391 |
Accessions | AAC12680 CAC69380 EAW69576 O60391 AY507106 AAS87020 AY507107 AAS87021 BC156390 AAI56391 BK000070 DAA00018 BK004079 DAA04570 CB243197 XM_011527669 XP_011525971 NM_138690 NP_619635 |
Function | NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. |
Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Note=Requires the presence of GRIN1 to be targeted at the plasma membrane. {ECO:0000250}. |
Top Pathways | Glutamatergic synapse, Amphetamine addiction, Nicotine addiction, Cocaine addiction, Alcoholism |
NR3B CRISPR/Cas9 KO Plasmid (h) - sc-406162 from Santa Cruz Biotechnology
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NR3B HDR Plasmid (h) - sc-406162-HDR from Santa Cruz Biotechnology
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NR3B Double Nickase Plasmid (h) - sc-406162-NIC from Santa Cruz Biotechnology
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NR3B Double Nickase Plasmid (h2) - sc-406162-NIC-2 from Santa Cruz Biotechnology
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NR3B CRISPR Activation Plasmid (h) - sc-406162-ACT from Santa Cruz Biotechnology
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NR3B CRISPR Activation Plasmid (h2) - sc-406162-ACT-2 from Santa Cruz Biotechnology
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NR3B Lentiviral Activation Particles (h) - sc-406162-LAC from Santa Cruz Biotechnology
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NR3B Lentiviral Activation Particles (h2) - sc-406162-LAC-2 from Santa Cruz Biotechnology
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NR3B siRNA (h) - sc-62701 from Santa Cruz Biotechnology
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NR3B shRNA Plasmid (h) - sc-62701-SH from Santa Cruz Biotechnology
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NR3B shRNA (h) Lentiviral Particles - sc-62701-V from Santa Cruz Biotechnology
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NMDAR3B RNAi - H00116444-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN9690 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9690 from Sigma-Aldrich
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GRIN3B siRNA (Human) - CRJ4517 from Cohesion Biosciences
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GRIN3B - MBS8215781 from MyBioSource
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shRNA set against Human GRIN3B (NM_138690.1) - SHH307958 from Creative biogene
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shRNA set against Human GRIN3B(NM_138690.1) - SHH104951 from Creative biogene
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NR3B CRISPR/Cas9 KO Plasmid (h2) - sc-406162-KO-2 from Santa Cruz Biotechnology
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NR3B HDR Plasmid (h2) - sc-406162-HDR-2 from Santa Cruz Biotechnology
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Human GRIN3B siRNA - orb275018 from Biorbyt
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GRIN3B shRNA Plasmid (Human) - CHJ4517 from Cohesion Biosciences
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GRIN3B miRNA 3'UTR clone - MiUTR1H-04275 from Creative biogene
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