| Gene Symbol |
NFATC4
|
| Entrez Gene |
4776
|
| Alt Symbol |
NF-AT3, NF-ATC4, NFAT3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
|
| Other Description |
T-cell transcription factor NFAT3|nuclear factor of activated T-cells, cytoplasmic 4
|
| Swissprots |
Q14934 B5B2W0 B5B2W9 B5B2X0 B5B2V5 B5B2V0 B5B2W5 B5B2W8 B5B2V3 Q7Z598 B5B2W6 B5B2V2 B4DDG5 B5B2W7 B5B2V7 B5B2W1 B5B2V4 B5B2U7 B5B2V1 B5B2W4 B5B2V9 B5B2U8 B5B2V8 B5B2W3 B4DY55 Q96H68 B5B2W2 B5B2U9
|
| Accessions |
CCO13781 EAW66020 Q14934 AK293185 BAG56726 AK293873 BAG57262 AK300450 BAG62171 AK302271 BAG63617 AK309339 AK309907 AK310433 AK310445 AK311078 AK311425 BC008857 AAH08857 BC037735 BC053855 AAH53855 BG723088 DB372155 DC318153 DC403050 EU446638 ABZ92167 EU887632 ACG55652 EU887633 ACG55653 EU887634 ACG55654 EU887635 ACG55655 EU887636 ACG55656 EU887637 ACG55657 EU887638 ACG55658 EU887639 ACG55659 EU887640 ACG55660 EU887641 ACG55661 EU887642 ACG55662 EU887643 ACG55663 EU887644 ACG55664 EU887645 ACG55665 EU887646 ACG55666 EU887647 ACG55667 EU887648 ACG55668 EU887649 ACG55669 EU887650 ACG55670 EU887651 ACG55671 EU887652 ACG55672 EU887653 ACG55673 EU887654 ACG55674 EU887655 ACG55675 L41066 AAA79175 XM_011536797 XP_011535099 XM_011536798 XP_011535100 XM_011536799 XP_011535101 NM_001136022 NP_001129494 NM_001198965 NP_001185894 NM_001198966 NP_001185895 NM_001198967 NP_001185896 NM_001288802 NP_001275731 NM_004554 NP_004545
|
| Function |
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL- 4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons. {ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:7749981}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:18347059}. Nucleus {ECO:0000269|PubMed:18347059}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
|
| Tissue Specificity |
Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus. {ECO:0000269|PubMed:18675896}.
|
| Top Pathways |
Wnt signaling pathway, Axon guidance, HTLV-I infection, Oxytocin signaling pathway, cGMP-PKG signaling pathway
|