NFATC4

Gene Symbol NFATC4
Entrez Gene 4776
Alt Symbol NF-AT3, NF-ATC4, NFAT3
Species Human
Gene Type protein-coding
Description nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
Other Description T-cell transcription factor NFAT3|nuclear factor of activated T-cells, cytoplasmic 4
Swissprots Q14934 B5B2W0 B5B2W9 B5B2X0 B5B2V5 B5B2V0 B5B2W5 B5B2W8 B5B2V3 Q7Z598 B5B2W6 B5B2V2 B4DDG5 B5B2W7 B5B2V7 B5B2W1 B5B2V4 B5B2U7 B5B2V1 B5B2W4 B5B2V9 B5B2U8 B5B2V8 B5B2W3 B4DY55 Q96H68 B5B2W2 B5B2U9
Accessions CCO13781 EAW66020 Q14934 AK293185 BAG56726 AK293873 BAG57262 AK300450 BAG62171 AK302271 BAG63617 AK309339 AK309907 AK310433 AK310445 AK311078 AK311425 BC008857 AAH08857 BC037735 BC053855 AAH53855 BG723088 DB372155 DC318153 DC403050 EU446638 ABZ92167 EU887632 ACG55652 EU887633 ACG55653 EU887634 ACG55654 EU887635 ACG55655 EU887636 ACG55656 EU887637 ACG55657 EU887638 ACG55658 EU887639 ACG55659 EU887640 ACG55660 EU887641 ACG55661 EU887642 ACG55662 EU887643 ACG55663 EU887644 ACG55664 EU887645 ACG55665 EU887646 ACG55666 EU887647 ACG55667 EU887648 ACG55668 EU887649 ACG55669 EU887650 ACG55670 EU887651 ACG55671 EU887652 ACG55672 EU887653 ACG55673 EU887654 ACG55674 EU887655 ACG55675 L41066 AAA79175 XM_011536797 XP_011535099 XM_011536798 XP_011535100 XM_011536799 XP_011535101 NM_001136022 NP_001129494 NM_001198965 NP_001185894 NM_001198966 NP_001185895 NM_001198967 NP_001185896 NM_001288802 NP_001275731 NM_004554 NP_004545
Function Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL- 4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons. {ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:7749981}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:18347059}. Nucleus {ECO:0000269|PubMed:18347059}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
Tissue Specificity Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus. {ECO:0000269|PubMed:18675896}.
Top Pathways Wnt signaling pathway, Axon guidance, HTLV-I infection, Oxytocin signaling pathway, cGMP-PKG signaling pathway

NFAT3 (31G6) Rabbit mAb - 2188 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 31G6
Western blot analysis of total cell lysate from A204 cells, using NFAT3 (31G6) Rabbit mAb.

NFAT3 (23E6) Rabbit mAb - 2183 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 23E6
Western blot analysis of total cell lysates from A204, A10 and HeLa cells, using NFAT3 (23E6) Rabbit mAb.

NFAT3 Antibody - 4988 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

NFATc4 (A-2) - sc-271127 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NFATc4 (A-2): sc-271127. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

NFATc4 (B-2) - sc-271597 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NFATc4 (B-2): sc-271597. Western blot analysis of NFATc4 expression in non-transfected: sc-117752 (A) and human NFATc4 transfected: sc-116481 (B) 293T whole cell lysates.

NFATc4 (C-20) - sc-1153 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NFATc4 (C-20): sc-1153. Western blot analysis of NFATc4 expression in non-transfected: sc-117752 (A) and human NFATc4 transfected: sc-116481 (B) 293T whole cell lysates.

NFATc4 (F-3) - sc-271091 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NFATc4 (F-3): sc-271091. Western blot analysis of NFATc4 expression in non-transfected: sc-117752 (A) and human NFATc4 transfected: sc-116481 (B) 293T whole cell lysates.

NFATc4 (H-74) - sc-13036 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NFATc4 (H-74): sc-13036. Western blot analysis of NFATc4 expression in A-10 whole cell lysate.

NFATc4 (L-9) - sc-32985 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NFATc4 (L-9): sc-32985. Western blot analysis of NFATc4 expression in non-transfected: sc-117752 (A) and human NFATc4 transfected: sc-116481 (B) 293T whole cell lysates.

p-NFATc4 (22.S168/170) - sc-135770 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

p-NFATc4 (Ser 168/170) - sc-32630 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p-NFATc4 (Ser 168/170): sc-32630. Western blot analysis of NFATc4 phosphorylation in non-transfected: sc-117752 (A) and human NFATc4 transfected: sc-116481 (B) 293T whole cell lysates.

p-NFATc4 (80.S168/170) - sc-135771 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

p-NFATc4 (Ser 175) - sc-68708 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p-NFATc4 (Ser 175): sc-68708. Western blot analysis of NFATc4 phosphorylation in non-transfected: sc-117752 (A) and human NFATc4 transfected: sc-116481 (B) 293T whole cell lysates.

p-NFATc4 (Ser 259) - sc-32986 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

p-NFATc4 (281/285) - sc-32987 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

p-NFATc4 (Ser 178) - sc-68710 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p-NFATc4 (Ser 178): sc-68710. Western blot analysis of NFATc4 phosphorylation in non-transfected: sc-117752 (A) and human NFATc4 transfected: sc-116481 (B) 293T whole cell lysates.

p-NFATc4 (Ser 334) - sc-32988 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-NFATC4 (phospho S168 + S170) antibody - ab111929 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111929 at 1/50 dilution staining NFATC4 in paraffin-embedded Human Breast carcinoma tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.

Anti-NFATC4 antibody - ab62613 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of HeLa cells, using ab62613 at a 1:500 dilution.Left image untreated.Right image treated with peptide.

Anti-NFATC4 antibody - ab3447 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of NFATC4 in A431 cells. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control - right) or with ab3447 at a dilution of 1:100 overnight at 4°C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody. NFATC4 staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Images were taken at 60X magnification.

Anti-NFATC4 antibody - ab99431 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate carcinoma tissue labelling NFATC4 with ab99431 at 1/1000 (0.2µg/ml). Detection: DAB.

Anti-NFATC4 antibody - ab129309 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab129309 at 3.75 &microg/ml staining NFATC4 in Formalin-fixed, Paraffin-embedded Human placenta tissue by Immunohistochemistry.

Anti-NFATC4 antibody - ab93625 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NFATC4 antibody (ab93625) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-NFATC4 antibody - ab183117 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NFATC4 antibody (ab183117) at 1/400 dilutionLane 1 : NIH/3T3 cell lysateLane 2 : Jurkat cell lysateLysates/proteins at 40 µg per lane.SecondaryGoat Anti-rabbit HRP at 1/10000 dilution

Anti-NFATC4 antibody - ab66781 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-NFATC4 antibody (ab66781) at 1.25 µg/ml + Transfected 293T cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution
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