Prkaca

Gene Symbol Prkaca
Entrez Gene 25636
Alt Symbol Cs-PKA, PKCA1
Species Rat
Gene Type protein-coding
Description protein kinase, cAMP-dependent, catalytic, alpha
Other Description PKA C-alpha|cAMP-dependent protein kinase catalytic subunit C alpha|cAMP-dependent protein kinase catalytic subunit alpha|protein kinase A
Swissprots P27791 Q6UA68
Accessions EDL92251 P27791 AY375243 AAQ81631 BC129128 AAI29129 FQ213798 X57986 CAA41052 XM_006255219 XP_006255281 NM_001100922 NP_001094392
Function Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B- alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasi
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. Distributed throughout the cytoplasm in meiotically incompetent oocytes. Associated to mitochondrion as meiotic competence is acquired. Aggregates around the germinal vesicles (GV) at the immature GV stage oocytes (By similarity). {ECO:0000250}.
Tissue Specificity Ubiquitously expressed. Isoform 2 is round spermatid specific. {ECO:0000269|PubMed:14514679, ECO:0000269|PubMed:1711374}.
Top Pathways cAMP signaling pathway, Estrogen signaling pathway, Proteoglycans in cancer, Glucagon signaling pathway, HTLV-I infection

CAMP-dependent protein kinase catalytic subunit alpha (PRKACA), Rat, ELISA Kit - E02C2401 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

cAMP-dependent protein kinase catalytic subunit alpha, Prkaca, Rat, ELISA Kit - E1918r from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t

Prkaca - EKR1222 from Nordic BioSite

Sensitivity 0.188ng/ml
Range 0.312-20ng/ml

Rat Prkaca ELISA Kit - E087317 from Biobool

Category ELISA Kit

Prkaca ELISA Kit (Rat) (OKEH04738) - OKEH04738 from Aviva Systems Biology

Category ELISA Kit
Prices $425.00
Sizes 96 wells
Sensitivity < 0.15 ng/mL
Range 0.312 - 20 ng/mL

Rat cAMP-dependent protein kinase catalytic subunit alpha ELISA Kit - EK4082 from Signalway Antibody

Category ELISA Kit
Prices $599.00
Sizes 1x96t
Range 0.78-50 ng/mL

Rat CAMP-dependent protein kinase catalytic subunit alpha (PRKACA) ELISA Kit - AE26007RA from ARP American Research Products

Category ELISA Kit
Prices $610.00
Sizes 96 t

cAMP-Dependent Protein Kinase Catalytic Subunit Alpha (PRKACA), ELISA Kit - MBS9357397 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-Dependent Protein Kinase Catalytic Subunit Alpha (PRKACA), ELISA Kit - MBS9350563 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-Dependent Protein Kinase Catalytic Subunit Alpha (PRKACA), ELISA Kit - MBS9349364 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-Dependent Protein Kinase Catalytic Subunit Alpha (PRKACA), ELISA Kit - MBS9357299 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-Dependent Protein Kinase Catalytic Subunit Alpha (PRKACA), ELISA Kit - MBS9345797 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-Dependent Protein Kinase Catalytic Subunit Alpha (PRKACA), ELISA Kit - MBS9368606 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-Dependent Protein Kinase Catalytic Subunit Alpha (PRKACA), ELISA Kit - MBS9364254 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-Dependent Protein Kinase Catalytic Subunit Alpha (PRKACA), ELISA Kit - MBS9346504 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-Dependent Protein Kinase Catalytic Subunit Alpha (PRKACA), ELISA Kit - MBS9353104 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-Dependent Protein Kinase Catalytic Subunit Alpha (PRKACA), ELISA Kit - MBS9346526 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-Dependent Protein Kinase Catalytic Subunit Alpha (PRKACA), ELISA Kit - MBS9360129 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-Dependent Protein Kinase Catalytic Subunit Alpha (PRKACA), ELISA Kit - MBS9357930 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-Dependent Protein Kinase Catalytic Subunit Alpha (PRKACA), ELISA Kit - MBS9355577 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-dependent protein kinase catalytic subunit alpha, ELISA Kit - MBS2533455 from MyBioSource

Category ELISA Kit
Prices $410.00, $490.00, $2,040.00, $3,590.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.938ng/mL
Range 1.563-100ng/mL

cAMP-dependent protein kinase catalytic subunit alpha, ELISA Kit - MBS765821 from MyBioSource

Category ELISA Kit
Prices $295.00, $390.00, $1,615.00, $3,015.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.469ng/ml
Range 0.78-50ng/ml

cAMP-Dependent Protein Kinase Catalytic Subunit Alpha (PRKACA), ELISA Kit - MBS9350973 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-dependent protein kinase catalytic subunit alpha, ELISA Kit - MBS765464 from MyBioSource

Category ELISA Kit
Prices $295.00, $390.00, $1,615.00, $3,015.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.188ng/ml
Range 0.312-20ng/ml

cAMP-Dependent Protein Kinase Catalytic Subunit Alpha (PRKACA), ELISA Kit - MBS9366248 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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