| Gene Symbol |
Prkaca
|
| Entrez Gene |
25636
|
| Alt Symbol |
Cs-PKA, PKCA1
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
protein kinase, cAMP-dependent, catalytic, alpha
|
| Other Description |
PKA C-alpha|cAMP-dependent protein kinase catalytic subunit C alpha|cAMP-dependent protein kinase catalytic subunit alpha|protein kinase A
|
| Swissprots |
P27791 Q6UA68
|
| Accessions |
EDL92251 P27791 AY375243 AAQ81631 BC129128 AAI29129 FQ213798 X57986 CAA41052 XM_006255219 XP_006255281 NM_001100922 NP_001094392
|
| Function |
Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B- alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasi
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. Distributed throughout the cytoplasm in meiotically incompetent oocytes. Associated to mitochondrion as meiotic competence is acquired. Aggregates around the germinal vesicles (GV) at the immature GV stage oocytes (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed. Isoform 2 is round spermatid specific. {ECO:0000269|PubMed:14514679, ECO:0000269|PubMed:1711374}.
|
| Top Pathways |
cAMP signaling pathway, Estrogen signaling pathway, Proteoglycans in cancer, Glucagon signaling pathway, HTLV-I infection
|