MBNL2

Gene Symbol	MBNL2
Entrez Gene	10150
Alt Symbol	MBLL, MBLL39, PRO2032
Species	Human
Gene Type	protein-coding
Description	muscleblind-like splicing regulator 2
Other Description	muscleblind-like 2|muscleblind-like protein 1|muscleblind-like protein 2|muscleblind-like protein-like 39
Swissprots	Q8NEV3 Q58F19 Q8TD82 Q3SXY5 Q5VZF2
Accessions	EAX08968 EAX08969 EAX08970 EAX08971 Q5VZF2 AF061261 AAC67242 AF116683 AAF71103 AF339782 AF339832 AF491866 AAM09798 AK291727 BAF84416 AK304699 BAG65469 AK315844 BAF98735 AV733599 AY101770 AAM50085 BC020418 AAH20418 BC020430 BC032426 AAH32426 BC104038 AAI04039 BC104039 AAI04040 BC104040 AAI04041 BE246602 CA429672 CR749802 CAH18662 DW415513 EU446757 ABZ92286 XM_005254018 XP_005254075 XM_005254019 XP_005254076 XM_005254020 XP_005254077 XM_005254021 XP_005254078 XM_005254022 XP_005254079 XM_006719912 XP_006719975 XM_011521045 XP_011519347 NM_001306070 NP_001292999 NM_144778 NP_659002 NM_207304 NP_997187
Function	Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM). {ECO:0000269|PubMed:15257297, ECO:0000269|PubMed:16273094, ECO:0000269|PubMed:16946708}.
Subcellular Location	Nucleus. Cytoplasm. Note=Greater concentration in the nucleus. Expressed in or near large cytoplasmic adhesion plaques. Location in the cytoplasm is microtubule-dependent. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.
Tissue Specificity	Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11929853}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MBNL2 (D-1) - sc-365104 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

MBNL2 (3B4) - sc-136167 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

MBNL2 (H-81) - sc-134813 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

MBNL2 (P-14) - sc-50090 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MBNL2 (Z-24) - sc-133774 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/0.5 ml Host Rabbit Clonality Polyclonal

Anti-MBNL2 antibody - ab171551 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-MBNL2 antibody - ab105331 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MBNL2 Antibody (aa261-290, APC) - LS-C237453 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MBNL2 Antibody (aa261-290, AP) - LS-C237452 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MBNL2 Antibody (aa261-290, Biotin) - LS-C237454 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MBNL2 Antibody (aa261-290, FITC) - LS-C237456 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MBNL2 Antibody (aa261-290, Azide-free, HRP) - LS-C248775 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MBNL2 Antibody (aa261-290, PE) - LS-C237458 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MBNL2 Antibody (aa260-290) - LS-C322890 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MBNL2 Antibody (aa1-80) - LS-C308908 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-MBNL2 Antibody (aa46-95) - LS-C82665 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-MBNL2 Antibody (aa51-100) - LS-C205713 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-MBNL2 Antibody (aa261-290) - LS-C164061 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

MBNL2 Antibody - NBP1-79451 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MBNL2 Antibody (3C3) - H00010150-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3C3

Anti-MBNL2 antibody produced in rabbit - AV51632 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

Monoclonal Anti-MBNL2 antibody produced in mouse - SAB1401510 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3C3

ANTI-MBNL2(C-TERMINAL) antibody produced in rabbit - SAB1307165 from Sigma-Aldrich Prices $326.00 Sizes 40 tst Host Rabbit Clonality Polyclonal

MBNL2 antibody - middle region (ARP51632_P050) - ARP51632_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MBNL2-Antibody-C-term - AP13023b from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

Search more