MBNL2

Gene Symbol MBNL2
Entrez Gene 10150
Alt Symbol MBLL, MBLL39, PRO2032
Species Human
Gene Type protein-coding
Description muscleblind-like splicing regulator 2
Other Description muscleblind-like 2|muscleblind-like protein 1|muscleblind-like protein 2|muscleblind-like protein-like 39
Swissprots Q8NEV3 Q58F19 Q8TD82 Q3SXY5 Q5VZF2
Accessions EAX08968 EAX08969 EAX08970 EAX08971 Q5VZF2 AF061261 AAC67242 AF116683 AAF71103 AF339782 AF339832 AF491866 AAM09798 AK291727 BAF84416 AK304699 BAG65469 AK315844 BAF98735 AV733599 AY101770 AAM50085 BC020418 AAH20418 BC020430 BC032426 AAH32426 BC104038 AAI04039 BC104039 AAI04040 BC104040 AAI04041 BE246602 CA429672 CR749802 CAH18662 DW415513 EU446757 ABZ92286 XM_005254018 XP_005254075 XM_005254019 XP_005254076 XM_005254020 XP_005254077 XM_005254021 XP_005254078 XM_005254022 XP_005254079 XM_006719912 XP_006719975 XM_011521045 XP_011519347 NM_001306070 NP_001292999 NM_144778 NP_659002 NM_207304 NP_997187
Function Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM). {ECO:0000269|PubMed:15257297, ECO:0000269|PubMed:16273094, ECO:0000269|PubMed:16946708}.
Subcellular Location Nucleus. Cytoplasm. Note=Greater concentration in the nucleus. Expressed in or near large cytoplasmic adhesion plaques. Location in the cytoplasm is microtubule-dependent. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.
Tissue Specificity Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11929853}.

Human MBNL2 full length protein - ab160843 from Abcam

Category Protein
Source Wheat germ
Species Human
ab160843 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human MBNL2 protein fragment - ab160844 from Abcam

Category Protein
Source Wheat germ
Species Human
ab160844 on a 12.5% SDS-PAGE stained with Coomassie Blue.

MBNL2 Antibody Blocking Peptide - LS-E2122 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human MBNL2 Protein - H00010150-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Recombinant Human MBNL2 Protein - H00010150-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

MBNL2-Antibody-C-term-Blocking-peptide - BP13023b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

MBNL2 Blocking Peptide - 33R-2607 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

MBNL2 - H00010150-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

MBNL2 - H00010150-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

MBNL2 - H00010150-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

MBNL2 - H00010150-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

MBNL2 fusion protein - Ag17240 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

MBNL2 fusion protein - Ag16035 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

Recombinant Human MBNL2, His-tagged - MBNL2-766H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human Muscleblind-like protein 2(MBNL2) - CSB-YP736209HU CSB-EP736209HU CSB-BP736209HU CSB-MP736209HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

MBNL2 (transcript variant 3) - TP319730 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
MBNL2

MBNL2 Peptide, Human - M34GP09284H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

MBNL2 Recombinant Protein Antigen - NBP2-57273PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

Muscleblind-like protein 2 (MBNL2), Recombinant Protein - MBS1311690 from MyBioSource

Category Protein
Prices $1,140.00, $1,140.00, $1,370.00, $1,370.00, $1,815.00, $1,815.00, $2,280.00, $2,280.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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