| Gene Symbol |
KCNA1
|
| Entrez Gene |
3736
|
| Alt Symbol |
AEMK, EA1, HBK1, HUK1, KV1.1, MBK1, MK1, RBK1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, voltage gated shaker related subfamily A, member 1
|
| Other Description |
potassium voltage-gated channel subfamily A member 1|potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)|voltage-gated K(+) channel HuKI|voltage-gated potassium channel HBK1|voltage-gated potassium channel subunit Kv1.1
|
| Swissprots |
Q3MIQ9 Q09470 A6NM83
|
| Accessions |
EAW88833 Q09470 AK094760 AK124568 BC101733 AAI01734 BC112180 AAI12181 DA236475 L02750 AAA36139 NM_000217 NP_000208
|
| Function |
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney (PubMed:19903818). Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability (PubMed:17156368). Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12077175, PubMed:17156368). Channel properties are modulated by cytoplasmic beta subunits that regulat
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:12077175, ECO:0000269|PubMed:15837928, ECO:0000269|PubMed:17136396, ECO:0000269|PubMed:17156368, ECO:0000269|PubMed:19307729, ECO:0000269|PubMed:19903818, ECO:0000269|PubMed:19912772, ECO:0000269|PubMed:19968958, ECO:0000269|PubMed:23903368}; Multi- pass membrane protein {ECO:0000305}. Membrane {ECO:0000269|PubMed:11086297}. Cell projection, axon {ECO:0000269|PubMed:11086297}. Cytoplasmic vesicle {ECO:0000269|PubMed:23774215}. Perikaryon {ECO:0000250|UniProtKB:P10499}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P10499}. Cell projection, dendrite {ECO:0000250|UniProtKB:P16388}. Cell junction {ECO:0000250|UniProtKB:P16388}. Cell junction, synapse {ECO:0000250|UniProtKB:P16388}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250|UniProtKB:P10499}. Note=Homotetrameric KCNA1 is primarily located in the endoplasmic reticulum. Interaction with KCNA2 and KCNAB2 or with KCNA4 and KCNAB2 promotes expression at the cell membrane (By similarity). Det
|
| Tissue Specificity |
Detected adjacent to nodes of Ranvier in juxtaparanodal zones in spinal cord nerve fibers, but also in paranodal regions in some myelinated spinal cord axons (at protein level) (PubMed:11086297). Detected in the islet of Langerhans (PubMed:21483673). {ECO:0000269|PubMed:11086297, ECO:0000269|PubMed:21483673}.
|