KCNA1

Gene Symbol	KCNA1
Entrez Gene	3736
Alt Symbol	AEMK, EA1, HBK1, HUK1, KV1.1, MBK1, MK1, RBK1
Species	Human
Gene Type	protein-coding
Description	potassium channel, voltage gated shaker related subfamily A, member 1
Other Description	potassium voltage-gated channel subfamily A member 1|potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)|voltage-gated K(+) channel HuKI|voltage-gated potassium channel HBK1|voltage-gated potassium channel subunit Kv1.1
Swissprots	Q3MIQ9 Q09470 A6NM83
Accessions	EAW88833 Q09470 AK094760 AK124568 BC101733 AAI01734 BC112180 AAI12181 DA236475 L02750 AAA36139 NM_000217 NP_000208
Function	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney (PubMed:19903818). Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability (PubMed:17156368). Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12077175, PubMed:17156368). Channel properties are modulated by cytoplasmic beta subunits that regulat
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12077175, ECO:0000269|PubMed:15837928, ECO:0000269|PubMed:17136396, ECO:0000269|PubMed:17156368, ECO:0000269|PubMed:19307729, ECO:0000269|PubMed:19903818, ECO:0000269|PubMed:19912772, ECO:0000269|PubMed:19968958, ECO:0000269|PubMed:23903368}; Multi- pass membrane protein {ECO:0000305}. Membrane {ECO:0000269|PubMed:11086297}. Cell projection, axon {ECO:0000269|PubMed:11086297}. Cytoplasmic vesicle {ECO:0000269|PubMed:23774215}. Perikaryon {ECO:0000250|UniProtKB:P10499}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P10499}. Cell projection, dendrite {ECO:0000250|UniProtKB:P16388}. Cell junction {ECO:0000250|UniProtKB:P16388}. Cell junction, synapse {ECO:0000250|UniProtKB:P16388}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250|UniProtKB:P10499}. Note=Homotetrameric KCNA1 is primarily located in the endoplasmic reticulum. Interaction with KCNA2 and KCNAB2 or with KCNA4 and KCNAB2 promotes expression at the cell membrane (By similarity). Det
Tissue Specificity	Detected adjacent to nodes of Ranvier in juxtaparanodal zones in spinal cord nerve fibers, but also in paranodal regions in some myelinated spinal cord axons (at protein level) (PubMed:11086297). Detected in the islet of Langerhans (PubMed:21483673). {ECO:0000269|PubMed:11086297, ECO:0000269|PubMed:21483673}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Kv1.1 potassium channel full length protein - ab132378 from Abcam Category Protein Source Wheat germ Species Human

Human Kv1.1 potassium channel protein fragment - ab114350 from Abcam Category Protein Source Wheat germ Species Human

Rat Kv1.1 potassium channel peptide - ab32432 from Abcam Category Peptide

KCNA1 / Kv1.1 Antibody Blocking Peptide - LS-E3548 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCNA1 / Kv1.1 Antibody Blocking Peptide - LS-E12440 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Kv1.1 Protein - H00003736-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Kv1.1 Partial Recombinant Protein - H00003736-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

KCNA1-Antibody-Center-Blocking-Peptide - BP14746c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human KCNA1 protein - orb244316 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

KCNA1 Blocking Peptide - 33R-4154 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Kv1.1 Blocking Peptide - abx062834 from Abbexa Category Peptide Species Human, Mouse, Rat, Dog, Pig

KCNA1 - H00003736-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

KCNA1 - H00003736-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

KCNA1 - H00003736-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

KCNA1 - H00003736-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

KCNA1 fusion protein - Ag12699 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

KCNA1 fusion protein - ag12563 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human KCNA1 - KCNA1-29199TH from Creative Biomart Category Protein Source Wheat germ Species Human

Kv1.1 Blocking Peptide - CBP1640 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Dog, Pig

Kv1.1 Peptide - BS5777P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant human Potassium voltage-gated channel subfamily A member 1 protein - CSB-EP012005HU CSB-BP012005HU CSB-MP012005HU from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant human Potassium voltage-gated channel subfamily A member 1 protein - CSB-YP012005HU from Cusabio Category Protein Source E.coli Species Human

Potassium voltage-gated channel subfamily A member 1 protein - RPC141025 from Biomatik Category Protein Prices $299.20, $352.00, $550.00, $687.50, $997.50, $1,507.50 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Potassium voltage-gated channel subfamily A member 1 protein, Recombinant Protein - MBS1265383 from MyBioSource Category Protein Prices $195.00, $465.00, $815.00, $1,290.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 1 mg (E-Coli) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Recombinant human Potassium voltage-gated channel subfamily A member 1 protein (OPCA00142) - OPCA00142 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

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