| Gene Symbol | RASSF1 |
|---|---|
| Entrez Gene | 11186 |
| Alt Symbol | 123F2, NORE2A, RASSF1A, RDA32, REH3P21 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Ras association (RalGDS/AF-6) domain family member 1 |
| Other Description | WUGSC:H_LUCA12.5|cardiac-specific ras association domain family 1 protein|pancreas-specific ras association domain family 1 protein|ras association domain-containing protein 1|tumor suppressor protein RDA32 |
| Swissprots | O60710 Q9HB04 Q9NS23 Q9HB18 Q9NS22 Q5TZT2 Q0VGC6 O60539 O14571 B7ZLL1 Q9UND4 Q9UND5 |
| Accessions | AAB67312 ABD97859 EAW65098 EAW65099 EAW65100 EAW65101 EAW65102 Q9NS23 AF040703 AAC70910 AF061836 AAC16001 AF102770 AAF35127 AF102771 AAF35128 AF102772 AAF35129 AF132675 AAD44174 AF132676 AAD44175 AF132677 AAD44176 AF286217 AAG10038 AF291719 AAG10064 AK292638 BAF85327 AK300994 BAG62613 AK310032 BC110412 AAI10413 BC117153 AAI17154 BC143879 AAI43880 BE247372 BI915594 BI966696 BM152368 BM562405 BQ072763 BT020047 AAV38850 BT020048 AAV38851 XM_011533315 XP_011531617 XM_011533316 XP_011531618 NM_001206957 NP_001193886 NM_007182 NP_009113 NM_170712 NP_733830 NM_170713 NP_733831 NM_170714 NP_733832 NM_170715 NM_170716 NM_170717 |
| Function | Potential tumor suppressor. Required for death receptor- dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. {ECO:0000269|PubMed:10888881, |
| Subcellular Location | Isoform A: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. Colocalizes with MDM2 in the nucleus. |
| Tissue Specificity | Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells. {ECO:0000269|PubMed:10888881, ECO:0000269|PubMed:11333291}. |
| Top Pathways | Bladder cancer, Non-small cell lung cancer, Hippo signaling pathway, MicroRNAs in cancer |