RASSF1

Gene Symbol RASSF1
Entrez Gene 11186
Alt Symbol 123F2, NORE2A, RASSF1A, RDA32, REH3P21
Species Human
Gene Type protein-coding
Description Ras association (RalGDS/AF-6) domain family member 1
Other Description WUGSC:H_LUCA12.5|cardiac-specific ras association domain family 1 protein|pancreas-specific ras association domain family 1 protein|ras association domain-containing protein 1|tumor suppressor protein RDA32
Swissprots O60710 Q9HB04 Q9NS23 Q9HB18 Q9NS22 Q5TZT2 Q0VGC6 O60539 O14571 B7ZLL1 Q9UND4 Q9UND5
Accessions AAB67312 ABD97859 EAW65098 EAW65099 EAW65100 EAW65101 EAW65102 Q9NS23 AF040703 AAC70910 AF061836 AAC16001 AF102770 AAF35127 AF102771 AAF35128 AF102772 AAF35129 AF132675 AAD44174 AF132676 AAD44175 AF132677 AAD44176 AF286217 AAG10038 AF291719 AAG10064 AK292638 BAF85327 AK300994 BAG62613 AK310032 BC110412 AAI10413 BC117153 AAI17154 BC143879 AAI43880 BE247372 BI915594 BI966696 BM152368 BM562405 BQ072763 BT020047 AAV38850 BT020048 AAV38851 XM_011533315 XP_011531617 XM_011533316 XP_011531618 NM_001206957 NP_001193886 NM_007182 NP_009113 NM_170712 NP_733830 NM_170713 NP_733831 NM_170714 NP_733832 NM_170715 NM_170716 NM_170717
Function Potential tumor suppressor. Required for death receptor- dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. {ECO:0000269|PubMed:10888881,
Subcellular Location Isoform A: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. Colocalizes with MDM2 in the nucleus.
Tissue Specificity Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells. {ECO:0000269|PubMed:10888881, ECO:0000269|PubMed:11333291}.
Top Pathways Bladder cancer, Non-small cell lung cancer, Hippo signaling pathway, MicroRNAs in cancer

RASSF1 (H-65) - sc-28563 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RASSF1 (H-65): sc-28563. Western blot analysis of RASSF1 expression in MIA PaCa-2 whole cell lysate.

RASSF1 (N-15) - sc-18722 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RASSF1 (C-12) - sc-18724 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RASSF1 (3F3) - sc-58470 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/500 µl
Host Mouse
Clonality Monoclonal
RASSF1 (3F3): sc-58470. Western blot analysis of RASSF1 expression in HeLa whole cell lysate.

Anti-RASSF1 antibody - ab180801 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human stomach cancer tissue labelling RASSF1 with ab180801 at 1/200. Magnification: 400x.

Anti-RASSF1 antibody - ab203310 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human oral squamous cell tissue labeling RASSF1 with ab203310 at 1/200 dilution overnight at 4°C, followed by Goat Anti-Rabbit IgG, FITC conjugated secondary antibody at 1/200 dilution for 40 minutes at 37°C.

Anti-RASSF1 antibody - ab173506 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-RASSF1 antibody (ab173506) at 1/100 dilution + Mouse lung tissue lysate at 35 µgSecondaryAnti-rabbit HRP conjugated antibody at 1/10000 dilutiondeveloped using the ECL technique

Anti-RASSF1 antibody [8E4] - ab119423 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8E4
All lanes : Anti-RASSF1 antibody [8E4] (ab119423) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY RASSF1 cDNALysates/proteins at 5 µg per lane.

Anti-RASSF1 antibody [9A5] - ab118016 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9A5
All lanes : Anti-RASSF1 antibody [9A5] (ab118016) at 1/500 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY RASSF1 cDNALysates/proteins at 5 µg per lane.

Anti-RASSF1 antibody [EPR7127] - ab126764 from Abcam

Prices $99.00, $313.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7127
All lanes : Anti-RASSF1 antibody [EPR7127] (ab126764) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Human fetal liver cell lysateLane 3 : HepG2 cell lysateLane 4 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-RASSF1 antibody - C-terminal - ab196497 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-RASSF1 antibody - C-terminal (ab196497) at 1/500 dilution + 293T cell lysate

Anti-RASSF1a antibody - ab97749 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-RASSF1a antibody (ab97749) at 1/500 dilution + 293T whole cell lysate at 30 µg

Anti-RASSF1a antibody - ab52931 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal

Anti-RASSF1a antibody [114-10H1] - ab91212 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 114-10H1

Anti-RASSF1a antibody [3F3] - ab23950 from Abcam

Prices $392.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3F3
All lanes : Anti-RASSF1a antibody [3F3] (ab23950) at 1/1000 dilutionLane 1 : Hela (H) cell extractLane 2 : Mouse brain (MB) extractLane 3 : Mouse liver (ML) extractLane 4 : Mouse kidney (MK) extractLysates/proteins at 20 µg per lane.SecondaryGoat anti-mouse HRP conjugatedeveloped using the ECL technique

Anti-RASSF1C antibody - ab24419 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-RASSF1C antibody (ab24419) at 1/1000 dilutionLane 1 : Total protein extract from E. coli with ~50ng to 100ng of a negative control fusion protein with an irrelevant antigen at 20 ug Lane 2 : Total protein extract from E. coli with ~50ng to 500ng of the antigen fusion protein at 20 ug SecondaryRabbit anti-mouse IgG + IgM, (H+L) horseradish peroxidase conjugated at 1/5000 dilution

Anti-RASSF1 / RASSF1A Antibody (aa52-101) - LS-C38770 from LifeSpan Bioscience

Prices $355.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal

Anti-RASSF1 / RASSF1A Antibody (aa132-145) - LS-C55373 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-RASSF1 / RASSF1A Antibody (aa201-250) - LS-C135582 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RASSF1 / RASSF1A antibody LS-C135582 Western blot of Fetal Lung lysate. Antibody concentration 1 ug/ml.

Anti-RASSF1 / RASSF1A Antibody (clone 8E4) IHC-plus™ - LS-B10044 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 8E4
Anti-RASSF1 / RASSF1A antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10044 concentration 10 ug/ml.

Anti-RASSF1 / RASSF1A Antibody (clone 114-10H1) IHC-plus™ - LS-B3784 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 114-10H1
Anti-RASSF1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3784 concentration 20 ug/ml.

Anti-RASSF1 / RASSF1A Antibody (clone 2B11) - LS-C337262 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B11
IHC of paraffin-embedded Human prostate tissue using anti-RASSF1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).

Anti-RASSF1 / RASSF1A Antibody (Internal, clone EPR7127) - LS-C152368 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7127
IHC of paraffin embedded human colon tissue using anti-RASSF1 antibody.

Anti-RASSF1 / RASSF1A Antibody (aa103-132) - LS-C158808 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
RASSF1 Antibody western blot of mouse lung tissue lysates (35 ug/lane). The RASSF1 antibody detected the RASSF1 protein (arrow).

Anti-RASSF1 / RASSF1A Antibody (aa1-340, clone 3F3) - LS-C93793 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3F3
A431 cells were labeled with anti-RASSF1a(clone 3F3) mAb, and detection was using a biotinylated secondary antibody and Texas-red conj streptavidin.
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