H2AFX

Gene Symbol	H2AFX
Entrez Gene	3014
Alt Symbol	H2A.X, H2A/X, H2AX
Species	Human
Gene Type	protein-coding
Description	H2A histone family, member X
Other Description	H2AX histone|histone H2A.x|histone H2AX
Swissprots	Q6IAS5 P16104 Q4ZGJ7
Accessions	AAY22178 EAW67451 P16104 BC004915 AAH04915 BC011694 AAH11694 BC013416 AAH13416 CR457079 CAG33360 X14850 CAA32968 NM_002105 NP_002096
Function	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation. {ECO:0000269|PubMed:10959836, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:15201865}.
Subcellular Location	Nucleus. Chromosome.
Top Pathways	Systemic lupus erythematosus, Alcoholism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Histone H2A.X (phospho Y142) peptide - ab113997 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human gamma H2A.X (phospho S139) peptide - ab15645 from Abcam Category Peptide

Human gamma H2A.X (unmodified ) peptide - ab15646 from Abcam Category Peptide

Human Histone H2A.X (acetyl K5) peptide - ab173317 from Abcam Category Peptide

Human Histone H2A.X (unmodified ) peptide - ab15020 from Abcam Category Peptide Species Human

Human Histone H2A.X full length protein - ab134863 from Abcam Category Protein Source E. coli Species Human

Human Histone H2A.X peptide - ab114003 from Abcam Category Peptide Species Human

Human Histone H2A.X peptide - ab173318 from Abcam Category Peptide Species Human

H2AFX / H2AX Antibody Blocking Peptide - LS-E2645 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

H2AFX / H2AX Antibody Blocking Peptide - LS-E21320 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

H2AFX / H2AX Antibody Blocking Peptide - LS-E21321 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human H2AX His Protein - NBP1-42464 from Novus Biologicals Category Protein Prices $329.00 Sizes 10 µg Source E. coli Species Human

Recombinant Human H2AX Protein - H00003014-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

H2AX Partial Protein - H00003014-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

H2AFX-Antibody-C-term-Blocking-peptide - BP13716b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

H2AFX Blocking Peptide - 33R-2565 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

H2AFX Blocking Peptide - 33R-8485 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

H2AFX protein (His tag) - 80R-3403 from Fitzgerald Category Protein Prices $210.00 Sizes 50 µg Source E.coli

Histone H2A.X Blocking Peptide - abx062718 from Abbexa Category Peptide Species Human, Rabbit

Human H2AFX Protein - abx066971 from Abbexa Category Protein Source E.coli Species Human

Histone H2A.x - H00003014-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

Histone H2A.x - H00003014-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Histone H2A.x - H00003014-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

H2A Histone Family, Member X (H2AFX), Human - 20-9582 from ARP American Research Products Category Protein Prices $505.00 Sizes 50 µg Source E.coli Species Human

Histone H2A.X fusion protein - ag19289 from Proteintech Group Category Protein Species Human

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