H2AFX

Gene Symbol	H2AFX
Entrez Gene	3014
Alt Symbol	H2A.X, H2A/X, H2AX
Species	Human
Gene Type	protein-coding
Description	H2A histone family, member X
Other Description	H2AX histone|histone H2A.x|histone H2AX
Swissprots	Q6IAS5 P16104 Q4ZGJ7
Accessions	AAY22178 EAW67451 P16104 BC004915 AAH04915 BC011694 AAH11694 BC013416 AAH13416 CR457079 CAG33360 X14850 CAA32968 NM_002105 NP_002096
Function	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation. {ECO:0000269|PubMed:10959836, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:15201865}.
Subcellular Location	Nucleus. Chromosome.
Top Pathways	Systemic lupus erythematosus, Alcoholism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

H2A.X (pSer139) Human In-Cell ELISA Kit (IR) - ab131382 from Abcam Category ELISA Kit Prices $438.00 Sizes 1 x 96 tests

Mouse/Human/Rat H2AFX / H2AX ELISA Kit (Cell-Based ELISA) - LS-F2050 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 31.2-2000 pg/ml

Mouse/Human/Rat Phospho-H2AFX / H2AX (Ser139) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1529 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 31.2-2000 pg/ml

Goat anti-H2AX Antibody, Affinity Purified - PLA0294 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Rabbit anti-H2AX Antibody, Affinity Purified - PLA0023 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Human/Mouse/Rat Phospho-Histone H2AX (S139) Cell-Based ELISA - KCB2288 from R&D Systems Category ELISA Kit Prices $459.00 Sizes 1 kit

Human Phospho-Histone H2AX (S139) DuoSet IC Economy Pack - DYC2288E from R&D Systems Category ELISA Kit

Human Phospho-Histone H2AX (S139) DuoSet IC ELISA - DYC2288-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00, $1,395.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates), 1 pack (for 15 Plates)

Human Phospho-Histone H2AX (S139) DuoSet IC, 5 Plate - DYC2288-5 from R&D Systems Category ELISA Kit

Human H2AX (Phospho-S139) ELISA Kit - orb247217 from Biorbyt Category ELISA Kit Prices $893.00, $1,530.00, $3,273.00 Sizes 96 assays, 192 assays, 480 assays

Histone H2A.x, H2AFX, Human, ELISA Kit - E15010h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t

Human Phospho-H2AX (S139) ELISA - PEL-H2AX-S139 from RayBiotech Category ELISA Kit Prices $481.00, $866.00, $1,924.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Histone H2A.X Colorimetric Cell-Based ELISA Kit - CB5333 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Histone H2A.X (Phospho-Ser139) Colorimetric Cell-Based ELISA Kit - CBP1575 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

H2A histone family, member X, ELISA Kit - MBS9335115 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

H2A Histone Family, Member X (H2AFX), ELISA Kit - MBS2025103 from MyBioSource Category ELISA Kit Prices $410.00, $610.00, $830.00, $3,420.00, $6,200.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.059ng/mL. Range 0.156-10ng/mL

ELISA Kit for H2A Histone Family, Member X (H2AFX) - SEQ000Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

H2A.X Phosphorylation Assay Kit (Flow Cytometry) - 17-344 from EMD Millipore Category Assay Kit

MILLIPLEX MAP Phospho H2A.X (Ser139) Magnetic Bead MAPmate- Cell Signaling Single Plex - 46-692MAG from EMD Millipore

H2A.X Phosphorylation Assay Kit (Chemiluminescence Detection) - 17-327 from EMD Millipore Category Assay Kit

ELISA Kit for H2A Histone Family, Member X (H2AFX) - SEQ000Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Mouse H2AFX / H2AX ELISA Kit (Sandwich ELISA) - LS-F17626 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 31.2 Range 31.2-2000 pg/ml

Human H2AFX / H2AX ELISA Kit (Sandwich ELISA) - LS-F17627 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 pg/ml Range 31.2-2000 pg/ml

Human H2A Histone Family, Member X ELISA Kit - abx258164 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Human H2AFX / H2AX ELISA Kit (Sandwich ELISA) - LS-F25619 from LifeSpan Bioscience Category ELISA Kit Prices $850.00 Sizes 1 plate Sensitivity 0.059 ng/ml Range 31.2-2000 pg/ml

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